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Article: Targeting Abnormal Hematopoietic Stem Cells in Chronic Myeloid Leukemia and Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms

TitleTargeting Abnormal Hematopoietic Stem Cells in Chronic Myeloid Leukemia and Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms
Authors
Yung, YLee, EChu, HTYip, PKGill, H
Keywordsstem cells
chronic myeloid leukemia
myeloproliferative neoplasm
targeted therapy
Issue Date2021
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms
Citation
International Journal of Molecular Sciences, 2021, v. 22, p. article no. 659 How to Cite?
DOI: http://dx.doi.org/10.3390/ijms22020659
AbstractMyeloproliferative neoplasms (MPNs) are unique hematopoietic stem cell disorders sharing mutations that constitutively activate the signal-transduction pathways involved in haematopoiesis. They are characterized by stem cell-derived clonal myeloproliferation. The key MPNs comprise chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). CML is defined by the presence of the Philadelphia (Ph) chromosome and BCR-ABL1 fusion gene. Despite effective cytoreductive agents and targeted therapy, complete CML/MPN stem cell eradication is rarely achieved. In this review article, we discuss the novel agents and combination therapy that can potentially abnormal hematopoietic stem cells in CML and MPNs and the CML/MPN stem cell-sustaining bone marrow microenvironment.
Persistent Identifierhttp://hdl.handle.net/10722/295452
ISSN
1661-6596
2011 Impact Factor: 2.598
2020 SCImago Journal Rankings: 1.455
PubMed Central ID
PMC7827471
ISI Accession Number ID
WOS:000611288800001

 

DC FieldValueLanguage
dc.contributor.authorYung, Y-
dc.contributor.authorLee, E-
dc.contributor.authorChu, HT-
dc.contributor.authorYip, PK-
dc.contributor.authorGill, H-
dc.date.accessioned2021-01-25T11:15:08Z-
dc.date.available2021-01-25T11:15:08Z-
dc.date.issued2021-
dc.identifier.citationInternational Journal of Molecular Sciences, 2021, v. 22, p. article no. 659-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/295452-
dc.description.abstractMyeloproliferative neoplasms (MPNs) are unique hematopoietic stem cell disorders sharing mutations that constitutively activate the signal-transduction pathways involved in haematopoiesis. They are characterized by stem cell-derived clonal myeloproliferation. The key MPNs comprise chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). CML is defined by the presence of the Philadelphia (Ph) chromosome and BCR-ABL1 fusion gene. Despite effective cytoreductive agents and targeted therapy, complete CML/MPN stem cell eradication is rarely achieved. In this review article, we discuss the novel agents and combination therapy that can potentially abnormal hematopoietic stem cells in CML and MPNs and the CML/MPN stem cell-sustaining bone marrow microenvironment.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectstem cells-
dc.subjectchronic myeloid leukemia-
dc.subjectmyeloproliferative neoplasm-
dc.subjecttargeted therapy-
dc.titleTargeting Abnormal Hematopoietic Stem Cells in Chronic Myeloid Leukemia and Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms-
dc.typeArticle-
dc.identifier.emailGill, H: gillhsh@hku.hk-
dc.identifier.authorityGill, H=rp01914-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms22020659-
dc.identifier.pmid33440869-
dc.identifier.pmcidPMC7827471-
dc.identifier.scopuseid_2-s2.0-85099893488-
dc.identifier.hkuros321016-
dc.identifier.volume22-
dc.identifier.spagearticle no. 659-
dc.identifier.epagearticle no. 659-
dc.identifier.isiWOS:000611288800001-
dc.publisher.placeSwitzerland-

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