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Article: Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

TitleIdentification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
Authors
Issue Date2021
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2021, v. 12, p. article no. 772 How to Cite?
AbstractSystemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, severity and age of onset among different ancestral groups. Previous genetic studies have focused more on European populations, which appear to be the least affected. Consequently, the genetic variations that underlie the commonalities, differences and treatment options in SLE among ancestral groups have not been well elucidated. To address this, we undertake a genome-wide association study, increasing the sample size of Chinese populations to the level of existing European studies. Thirty-eight novel SLE-associated loci and incomplete sharing of genetic architecture are identified. In addition to the human leukocyte antigen (HLA) region, nine disease loci show clear ancestral differences and implicate antibody production as a potential mechanism for differences in disease manifestation. Polygenic risk scores perform significantly better when trained on ancestry-matched data sets. These analyses help to reveal the genetic basis for disparities in SLE among ancestral groups.
Persistent Identifierhttp://hdl.handle.net/10722/299764
ISSN
2021 Impact Factor: 17.694
2020 SCImago Journal Rankings: 5.559
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, YF-
dc.contributor.authorZhang, Y-
dc.contributor.authorLin, Z-
dc.contributor.authorZHANG, H-
dc.contributor.authorWang, TY-
dc.contributor.authorCAO, Y-
dc.contributor.authorMorris, DL-
dc.contributor.authorSheng, Y-
dc.contributor.authorYin, X-
dc.contributor.authorZhong, SL-
dc.contributor.authorGu, X-
dc.contributor.authorLEI, Y-
dc.contributor.authorHe, J-
dc.contributor.authorWu, Q-
dc.contributor.authorSHEN, J-
dc.contributor.authorYang, J-
dc.contributor.authorLam, TH-
dc.contributor.authorLin, JH-
dc.contributor.authorMai, Z-
dc.contributor.authorGUO, M-
dc.contributor.authorTang, Y-
dc.contributor.authorChen, Y-
dc.contributor.authorSong, Q-
dc.contributor.authorBan, B-
dc.contributor.authorMok, CC-
dc.contributor.authorCui, Y-
dc.contributor.authorLu, L-
dc.contributor.authorShen, N-
dc.contributor.authorSham, PC-
dc.contributor.authorLau, CS-
dc.contributor.authorSmith, DK-
dc.contributor.authorVyse, TJ-
dc.contributor.authorZhang, X-
dc.contributor.authorLau, YL-
dc.contributor.authorYang, W-
dc.date.accessioned2021-05-26T03:28:44Z-
dc.date.available2021-05-26T03:28:44Z-
dc.date.issued2021-
dc.identifier.citationNature Communications, 2021, v. 12, p. article no. 772-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/299764-
dc.description.abstractSystemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, severity and age of onset among different ancestral groups. Previous genetic studies have focused more on European populations, which appear to be the least affected. Consequently, the genetic variations that underlie the commonalities, differences and treatment options in SLE among ancestral groups have not been well elucidated. To address this, we undertake a genome-wide association study, increasing the sample size of Chinese populations to the level of existing European studies. Thirty-eight novel SLE-associated loci and incomplete sharing of genetic architecture are identified. In addition to the human leukocyte antigen (HLA) region, nine disease loci show clear ancestral differences and implicate antibody production as a potential mechanism for differences in disease manifestation. Polygenic risk scores perform significantly better when trained on ancestry-matched data sets. These analyses help to reveal the genetic basis for disparities in SLE among ancestral groups.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsNature Communications. Copyright © Nature Research: Fully open access journals.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleIdentification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups-
dc.typeArticle-
dc.identifier.emailWang, YF: yfwangbm@connect.hku.hk-
dc.identifier.emailYang, J: jingy09@hku.hk-
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hk-
dc.identifier.emailSham, PC: pcsham@hku.hk-
dc.identifier.emailLau, CS: cslau@hku.hk-
dc.identifier.emailSmith, DK: dsmith@hku.hk-
dc.identifier.emailLau, YL: lauylung@hku.hk-
dc.identifier.emailYang, W: yangwl@hku.hk-
dc.identifier.authorityLam, TH=rp00326-
dc.identifier.authoritySham, PC=rp00459-
dc.identifier.authorityLau, CS=rp01348-
dc.identifier.authorityLau, YL=rp00361-
dc.identifier.authorityYang, W=rp00524-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-021-21049-y-
dc.identifier.pmid33536424-
dc.identifier.pmcidPMC7858632-
dc.identifier.scopuseid_2-s2.0-85100413693-
dc.identifier.hkuros322517-
dc.identifier.volume12-
dc.identifier.spagearticle no. 772-
dc.identifier.epagearticle no. 772-
dc.identifier.isiWOS:000617330000016-
dc.publisher.placeUnited Kingdom-

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