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Article: Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis

TitleRoles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis
Authors
KeywordsIL-25
IL-25 signal transduction
type 2 inflammation
systemic erythematosus lupus
rheumatoid arthritis
Issue Date2021
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology
Citation
Frontiers in Immunology, 2021, v. 12, p. article no. 691559 How to Cite?
AbstractInterleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases. Compared with other IL-17 cytokine family members, IL-25 has relatively low sequence similarity to IL-17A and exhibits a distinct function from other IL-17 cytokines. IL-25 binds to its receptor composed of IL-17 receptor A (IL-17RA) and IL-17 receptor B (IL-17RB) for signal transduction. IL-25 has been implicated as a type 2 cytokine and can induce the production of IL-4, IL-5 and IL-13, which in turn inhibits the differentiation of T helper (Th) 17. In addition to its anti-inflammatory properties, IL-25 also exhibits a pro-inflammatory effect in the pathogenesis of Th17-dominated diseases. Here, we review recent advances in the roles of IL-25 in the pathogenesis of inflammation and autoimmune diseases.
Persistent Identifierhttp://hdl.handle.net/10722/305083
ISSN
2020 Impact Factor: 7.561
2020 SCImago Journal Rankings: 2.646
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDeng, C-
dc.contributor.authorPeng, N-
dc.contributor.authorTANG, Y-
dc.contributor.authorYu, N-
dc.contributor.authorWang, C-
dc.contributor.authorCai, X-
dc.contributor.authorZhang, L-
dc.contributor.authorHu, D-
dc.contributor.authorCiccia, F-
dc.contributor.authorLu, L-
dc.date.accessioned2021-10-05T02:39:29Z-
dc.date.available2021-10-05T02:39:29Z-
dc.date.issued2021-
dc.identifier.citationFrontiers in Immunology, 2021, v. 12, p. article no. 691559-
dc.identifier.issn1664-3224-
dc.identifier.urihttp://hdl.handle.net/10722/305083-
dc.description.abstractInterleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases. Compared with other IL-17 cytokine family members, IL-25 has relatively low sequence similarity to IL-17A and exhibits a distinct function from other IL-17 cytokines. IL-25 binds to its receptor composed of IL-17 receptor A (IL-17RA) and IL-17 receptor B (IL-17RB) for signal transduction. IL-25 has been implicated as a type 2 cytokine and can induce the production of IL-4, IL-5 and IL-13, which in turn inhibits the differentiation of T helper (Th) 17. In addition to its anti-inflammatory properties, IL-25 also exhibits a pro-inflammatory effect in the pathogenesis of Th17-dominated diseases. Here, we review recent advances in the roles of IL-25 in the pathogenesis of inflammation and autoimmune diseases.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology-
dc.relation.ispartofFrontiers in Immunology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectIL-25-
dc.subjectIL-25 signal transduction-
dc.subjecttype 2 inflammation-
dc.subjectsystemic erythematosus lupus-
dc.subjectrheumatoid arthritis-
dc.titleRoles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis-
dc.typeArticle-
dc.identifier.emailDeng, C: dchong12@connect.hku.hk-
dc.identifier.emailLu, L: liweilu@hku.hk-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fimmu.2021.691559-
dc.identifier.pmid34122457-
dc.identifier.pmcidPMC8194343-
dc.identifier.scopuseid_2-s2.0-85111022963-
dc.identifier.hkuros326249-
dc.identifier.volume12-
dc.identifier.spagearticle no. 691559-
dc.identifier.epagearticle no. 691559-
dc.identifier.isiWOS:000660087200001-
dc.publisher.placeSwitzerland-

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