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Article: Interrogation of Folic Acid-Functionalized Nanomedicines: The Regulatory Roles of Plasma Proteins Reexamined

TitleInterrogation of Folic Acid-Functionalized Nanomedicines: The Regulatory Roles of Plasma Proteins Reexamined
Authors
Keywordsfolic acid
nanomedicine
immunoglobulin
natural IgM
liposome
Issue Date2020
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/ancac3/index.html
Citation
ACS Nano, 2020, v. 14 n. 11, p. 14779-14789 How to Cite?
AbstractFolic acid (FA) has been extensively exploited to facilitate targeted delivery of nanomedicines by recognizing the folate receptor-α (FR-α) overexpressed in many human cancers. Unfortunately, none have been approved for clinical use yet. Here we reveal that FA functionalization induces heavy natural IgM absorption on the liposomal surface, depriving FA of receptor recognition and accelerating complement activation in vivo. FA functionalization does not enhance distribution of liposomes in FR-α-overexpressed tumors in comparison to plain liposomes (without FA), but leads to aggravated capture of liposomes by macrophages in the tumor, liver, and spleen. In addition, FA-functionalized polymeric nanoparticles are also vulnerable to natural IgM absorption. This work highlights the pivotal roles of natural IgM in regulating in vivo delivery of FA-functionalized nanomedicines. Due to the prevalent association of immune disorders and varying levels of immunoglobulins with cancer patients, extraordinary cautiousness is urged for clinical translation of FA-enabled targeted delivery systems.
Persistent Identifierhttp://hdl.handle.net/10722/305426
ISSN
2020 Impact Factor: 15.881
2020 SCImago Journal Rankings: 5.554
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, H-
dc.contributor.authorDing, T-
dc.contributor.authorGuan, J-
dc.contributor.authorLiu, X-
dc.contributor.authorWang, J-
dc.contributor.authorJin, P-
dc.contributor.authorHou, S-
dc.contributor.authorLu, W-
dc.contributor.authorQian, J-
dc.contributor.authorWang, W-
dc.contributor.authorZhan, C-
dc.date.accessioned2021-10-20T10:09:14Z-
dc.date.available2021-10-20T10:09:14Z-
dc.date.issued2020-
dc.identifier.citationACS Nano, 2020, v. 14 n. 11, p. 14779-14789-
dc.identifier.issn1936-0851-
dc.identifier.urihttp://hdl.handle.net/10722/305426-
dc.description.abstractFolic acid (FA) has been extensively exploited to facilitate targeted delivery of nanomedicines by recognizing the folate receptor-α (FR-α) overexpressed in many human cancers. Unfortunately, none have been approved for clinical use yet. Here we reveal that FA functionalization induces heavy natural IgM absorption on the liposomal surface, depriving FA of receptor recognition and accelerating complement activation in vivo. FA functionalization does not enhance distribution of liposomes in FR-α-overexpressed tumors in comparison to plain liposomes (without FA), but leads to aggravated capture of liposomes by macrophages in the tumor, liver, and spleen. In addition, FA-functionalized polymeric nanoparticles are also vulnerable to natural IgM absorption. This work highlights the pivotal roles of natural IgM in regulating in vivo delivery of FA-functionalized nanomedicines. Due to the prevalent association of immune disorders and varying levels of immunoglobulins with cancer patients, extraordinary cautiousness is urged for clinical translation of FA-enabled targeted delivery systems.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/ancac3/index.html-
dc.relation.ispartofACS Nano-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectfolic acid-
dc.subjectnanomedicine-
dc.subjectimmunoglobulin-
dc.subjectnatural IgM-
dc.subjectliposome-
dc.titleInterrogation of Folic Acid-Functionalized Nanomedicines: The Regulatory Roles of Plasma Proteins Reexamined-
dc.typeArticle-
dc.identifier.emailWang, W: wangwp@hku.hk-
dc.identifier.authorityWang, W=rp02227-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsnano.0c02821-
dc.identifier.pmid33084315-
dc.identifier.scopuseid_2-s2.0-85096110758-
dc.identifier.hkuros327367-
dc.identifier.volume14-
dc.identifier.issue11-
dc.identifier.spage14779-
dc.identifier.epage14789-
dc.identifier.isiWOS:000595533800029-
dc.publisher.placeUnited States-

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