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Article: Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles

TitleInduction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles
Authors
KUWENTRAI, CYu, JZhang, BZHu, YFDou, YGONG, HRHuang, JDXu, C
Issue Date2021
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jir/
Citation
Journal of Immunology Research, 2021, v. 2021, p. article no. 5531220 How to Cite?
DOI: http://dx.doi.org/10.1155/2021/5531220
AbstractThe nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses.
Persistent Identifierhttp://hdl.handle.net/10722/306272
ISSN
2314-8861
2021 Impact Factor: 4.493
2020 SCImago Journal Rankings: 1.315
PubMed Central ID
PMC8130907
ISI Accession Number ID
WOS:000659026200001

 

DC FieldValueLanguage
dc.contributor.authorKUWENTRAI, C-
dc.contributor.authorYu, J-
dc.contributor.authorZhang, BZ-
dc.contributor.authorHu, YF-
dc.contributor.authorDou, Y-
dc.contributor.authorGONG, HR-
dc.contributor.authorHuang, JD-
dc.contributor.authorXu, C-
dc.date.accessioned2021-10-20T10:21:15Z-
dc.date.available2021-10-20T10:21:15Z-
dc.date.issued2021-
dc.identifier.citationJournal of Immunology Research, 2021, v. 2021, p. article no. 5531220-
dc.identifier.issn2314-8861-
dc.identifier.urihttp://hdl.handle.net/10722/306272-
dc.description.abstractThe nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jir/-
dc.relation.ispartofJournal of Immunology Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleInduction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles-
dc.typeArticle-
dc.identifier.emailDou, Y: douying@hku.hk-
dc.identifier.emailHuang, JD: jdhuang@hku.hk-
dc.identifier.authorityHuang, JD=rp00451-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2021/5531220-
dc.identifier.pmid34056008-
dc.identifier.pmcidPMC8130907-
dc.identifier.scopuseid_2-s2.0-85107179393-
dc.identifier.hkuros326824-
dc.identifier.volume2021-
dc.identifier.spagearticle no. 5531220-
dc.identifier.epagearticle no. 5531220-
dc.identifier.isiWOS:000659026200001-
dc.publisher.placeUnited States-

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