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Article: Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.

TitleRole of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.
Authors
Khoo, USChan, KYChan, VSChing, JCYam, LChu, CMLai, STWong, TYTam, PYip, SPLeung, GMLin, CLPeiris, JS
Issue Date2008
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal, 2008, v. 14 suppl. 4, p. 31-35 How to Cite?
Abstract1. A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In contrast, homozygous L-SIGN demonstrated lower binding capacity for HIV1-gp120.3. Genetic-association studies for single nucleotide polymorphisms of the inflammatory response genes, namely TNF-alpha, INF-alpha, INF-beta, INF-gamma, IL1-alpha, IL1-beta, IL-4, IL-6 and iNOS, failed to show a significant association with SARS clinical outcomes or susceptibility.
DescriptionResearch Fund for the Control of Infectious Diseases: Research Dissemination Reports (Series 2)
Persistent Identifierhttp://hdl.handle.net/10722/57361
ISSN
1024-2708
2021 Impact Factor: 1.256
2020 SCImago Journal Rankings: 0.357

 

DC FieldValueLanguage
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorChan, KYen_HK
dc.contributor.authorChan, VSen_HK
dc.contributor.authorChing, JCen_HK
dc.contributor.authorYam, Len_HK
dc.contributor.authorChu, CMen_HK
dc.contributor.authorLai, STen_HK
dc.contributor.authorWong, TYen_HK
dc.contributor.authorTam, Pen_HK
dc.contributor.authorYip, SPen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorLin, CLen_HK
dc.contributor.authorPeiris, JSen_HK
dc.date.accessioned2010-04-12T01:34:18Z-
dc.date.available2010-04-12T01:34:18Z-
dc.date.issued2008en_HK
dc.identifier.citationHong Kong Medical Journal, 2008, v. 14 suppl. 4, p. 31-35en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57361-
dc.descriptionResearch Fund for the Control of Infectious Diseases: Research Dissemination Reports (Series 2)en_HK
dc.description.abstract1. A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In contrast, homozygous L-SIGN demonstrated lower binding capacity for HIV1-gp120.3. Genetic-association studies for single nucleotide polymorphisms of the inflammatory response genes, namely TNF-alpha, INF-alpha, INF-beta, INF-gamma, IL1-alpha, IL1-beta, IL-4, IL-6 and iNOS, failed to show a significant association with SARS clinical outcomes or susceptibility.en_HK
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong Medical Journalen_HK
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.en_HK
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subject.meshAdulten_HK
dc.subject.meshAllelesen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshCell Adhesion Molecules - geneticsen_HK
dc.subject.meshCommunicable Diseases - genetics - physiopathologyen_HK
dc.subject.meshConfidence Intervalsen_HK
dc.subject.meshCytokines - genetics - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Frequencyen_HK
dc.subject.meshGenetic Predisposition to Diseaseen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLectins, C-Type - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOdds Ratioen_HK
dc.subject.meshPolymorphism, Geneticen_HK
dc.subject.meshProbabilityen_HK
dc.subject.meshReceptors, Cell Surface - geneticsen_HK
dc.subject.meshSARS Virus - genetics - metabolismen_HK
dc.subject.meshSevere Acute Respiratory Syndrome - genetics - physiopathologyen_HK
dc.subject.meshTandem Repeat Sequencesen_HK
dc.subject.meshTumor Necrosis Factor-alpha - genetics - metabolismen_HK
dc.titleRole of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=14&issue=4 Suppl 4&spage=S31&epage=S35&date=2008&atitle=Role+of+polymorphisms+of+the+inflammatory+response+genes+and+DC-SIGNR+in+genetic+susceptibility+to+SARS+and+other+infectionsen_HK
dc.identifier.emailKhoo, US: uskhoo@hku.hken_HK
dc.identifier.emailChan, KY: kelvinc@pathology.hku.hken_HK
dc.identifier.emailChan, VS: sfvchan@hku.hken_HK
dc.identifier.emailTam, P: paultam@hku.hken_HK
dc.identifier.emailLeung, GM: gmleung@hku.hken_HK
dc.identifier.emailPeiris, JS: malik@hkucc.hku.hken_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityChan, KY=rp00453en_HK
dc.identifier.authorityChan, VS=rp01459en_HK
dc.identifier.authorityTam, P=rp00060en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authorityPeiris, JS=rp00410en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid18708672-
dc.identifier.scopuseid_2-s2.0-70449903273en_HK
dc.identifier.hkuros150914-
dc.identifier.volume14en_HK
dc.identifier.issuesuppl. 4-
dc.identifier.spage31en_HK
dc.identifier.epage35en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridChan, KY=7406034195en_HK
dc.identifier.scopusauthoridChan, VS=35200370000en_HK
dc.identifier.scopusauthoridChing, JC=15735635300en_HK
dc.identifier.scopusauthoridYam, L=7102764741en_HK
dc.identifier.scopusauthoridChu, CM=7404345558en_HK
dc.identifier.scopusauthoridLai, ST=7402937038en_HK
dc.identifier.scopusauthoridWong, TY=55350855600en_HK
dc.identifier.scopusauthoridTam, P=7202539421en_HK
dc.identifier.scopusauthoridYip, SP=7102133673en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridLin, CL=37099293900en_HK
dc.identifier.scopusauthoridPeiris, JS=7005486823en_HK
dc.identifier.issnl1024-2708-

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