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- Publisher Website: 10.1016/j.tripleo.2009.05.038
- Scopus: eid_2-s2.0-70349183230
- PMID: 19716721
- WOS: WOS:000270084800006
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Article: Comparison of gene expression of osteogenic factors between continuous and intermittent distraction osteogenesis in rabbit mandibular lengthening
Title | Comparison of gene expression of osteogenic factors between continuous and intermittent distraction osteogenesis in rabbit mandibular lengthening | ||||
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Authors | |||||
Issue Date | 2009 | ||||
Publisher | Mosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/tripleo | ||||
Citation | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology And Endodontology, 2009, v. 108 n. 4, p. 496-499 How to Cite? | ||||
Abstract | Objectives: This study aimed to evaluate the effect of distraction frequency on the gene expression of osteogenic mediators in mandibular distraction osteogenesis. Study design: Forty adult New Zealand white rabbits were randomly assigned to the continuous and intermittent distraction groups. Unilateral mandibular osteotomy was performed and custom-designed manual-driven or autodriven distractor was bridged over the osteotomy segments. Animals were humanely killed at day 6, day 10, day 14, and day 21 after osteotomy. mRNA expression of the osteogenic mediators in the distraction regenerate was examined by real-time polymerase chain reaction. Results: The expression of transforming growth factor-β1 was significantly higher at day 6, and the expression of the bone morphogenetic protein-2 was significantly higher from day 6 to day 14, in the continuous distraction group. Conclusion: High-frequency traction up-regulates the expression of osteogenic mediators contributing to the enhanced bone formation. © 2009 Mosby, Inc. All rights reserved. | ||||
Persistent Identifier | http://hdl.handle.net/10722/66693 | ||||
ISSN | 2011 Impact Factor: 1.457 | ||||
ISI Accession Number ID |
Funding Information: Project no. S-07-14Z was supported by the AO Research Fund of the AO foundation. | ||||
References |
DC Field | Value | Language |
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dc.contributor.author | Zheng, LW | en_HK |
dc.contributor.author | Ma, L | en_HK |
dc.contributor.author | Cheung, LK | en_HK |
dc.date.accessioned | 2010-09-06T05:48:32Z | - |
dc.date.available | 2010-09-06T05:48:32Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology And Endodontology, 2009, v. 108 n. 4, p. 496-499 | en_HK |
dc.identifier.issn | 1079-2104 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/66693 | - |
dc.description.abstract | Objectives: This study aimed to evaluate the effect of distraction frequency on the gene expression of osteogenic mediators in mandibular distraction osteogenesis. Study design: Forty adult New Zealand white rabbits were randomly assigned to the continuous and intermittent distraction groups. Unilateral mandibular osteotomy was performed and custom-designed manual-driven or autodriven distractor was bridged over the osteotomy segments. Animals were humanely killed at day 6, day 10, day 14, and day 21 after osteotomy. mRNA expression of the osteogenic mediators in the distraction regenerate was examined by real-time polymerase chain reaction. Results: The expression of transforming growth factor-β1 was significantly higher at day 6, and the expression of the bone morphogenetic protein-2 was significantly higher from day 6 to day 14, in the continuous distraction group. Conclusion: High-frequency traction up-regulates the expression of osteogenic mediators contributing to the enhanced bone formation. © 2009 Mosby, Inc. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Mosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/tripleo | en_HK |
dc.relation.ispartof | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology | en_HK |
dc.subject.mesh | Bone Morphogenetic Protein 2 - analysis | - |
dc.subject.mesh | Mandible - surgery | - |
dc.subject.mesh | Osteogenesis - genetics | - |
dc.subject.mesh | Osteogenesis, Distraction - instrumentation - methods | - |
dc.subject.mesh | Transforming Growth Factor beta1 - analysis | - |
dc.title | Comparison of gene expression of osteogenic factors between continuous and intermittent distraction osteogenesis in rabbit mandibular lengthening | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1079-2104&volume=108&issue=4&spage=496&epage=499&date=2009&atitle=Comparison+of+gene+expression+of+osteogenic+factors+between+continuous+and+intermittent+distraction+osteogenesis+in+rabbit+mandibular+lengthening | en_HK |
dc.identifier.email | Zheng, LW:lwzheng@hku.hk | en_HK |
dc.identifier.email | Cheung, LK:lkcheung@hkucc.hku.hk | en_HK |
dc.identifier.authority | Zheng, LW=rp01411 | en_HK |
dc.identifier.authority | Cheung, LK=rp00013 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.tripleo.2009.05.038 | en_HK |
dc.identifier.pmid | 19716721 | - |
dc.identifier.scopus | eid_2-s2.0-70349183230 | en_HK |
dc.identifier.hkuros | 167657 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-70349183230&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 108 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 496 | en_HK |
dc.identifier.epage | 499 | en_HK |
dc.identifier.isi | WOS:000270084800006 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Zheng, LW=11241247300 | en_HK |
dc.identifier.scopusauthorid | Ma, L=36071946000 | en_HK |
dc.identifier.scopusauthorid | Cheung, LK=7102302747 | en_HK |
dc.identifier.issnl | 1079-2104 | - |