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Article: Up-regulation of fibroblast growth factor 3 is associated with tumor metastasis and recurrence in human hepatocellular carcinoma

TitleUp-regulation of fibroblast growth factor 3 is associated with tumor metastasis and recurrence in human hepatocellular carcinoma
Authors
Hu, LSham, JSTXie, DWen, JMWang, WSWang, YGuan, XY
KeywordsFGF3
Hepatocellular carcinoma
hsr
Metastasis
Recurrence
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2007, v. 252 n. 1, p. 36-42 How to Cite?
DOI: http://dx.doi.org/10.1016/j.canlet.2006.12.003
AbstractRecently, we established a hepatocellular carcinoma (HCC) cell line (named H4-M) from a metastatic HCC tumor. In H4-M, a marker chromosome containing a homogeneously staining region (hsr) was identified by cytogenetic analysis. The hsr was characterized by chromosome microdissection and the result showed that the hsr was composed of DNA sequence from 11q13. Oncogenes CCND1 and FGF3 were localized within the complicon and overexpressions of CCND1 and FGF3 were confirmed by Northern blot analysis. Clinical significance of FGF3 overexpression was studied by immunohistochemistry (IHC) using an HCC tissue microarray (TMA) containing 60 pairs of primary/metastatic HCCs and 30 pairs of primary/recurrent HCCs. TMA study showed that overexpression of FGF3 was significantly associated with HCC metastasis and recurrence (p < 0.01), suggesting that up-regulation of FGF3 may play an important role in HCC metastasis and recurrence. © 2006 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/72015
ISSN
0304-3835
2021 Impact Factor: 9.756
2020 SCImago Journal Rankings: 2.470
ISI Accession Number ID
WOS:000247457600004
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorHu, Len_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorWen, JMen_HK
dc.contributor.authorWang, WSen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-09-06T06:37:30Z-
dc.date.available2010-09-06T06:37:30Z-
dc.date.issued2007en_HK
dc.identifier.citationCancer Letters, 2007, v. 252 n. 1, p. 36-42en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72015-
dc.description.abstractRecently, we established a hepatocellular carcinoma (HCC) cell line (named H4-M) from a metastatic HCC tumor. In H4-M, a marker chromosome containing a homogeneously staining region (hsr) was identified by cytogenetic analysis. The hsr was characterized by chromosome microdissection and the result showed that the hsr was composed of DNA sequence from 11q13. Oncogenes CCND1 and FGF3 were localized within the complicon and overexpressions of CCND1 and FGF3 were confirmed by Northern blot analysis. Clinical significance of FGF3 overexpression was studied by immunohistochemistry (IHC) using an HCC tissue microarray (TMA) containing 60 pairs of primary/metastatic HCCs and 30 pairs of primary/recurrent HCCs. TMA study showed that overexpression of FGF3 was significantly associated with HCC metastasis and recurrence (p < 0.01), suggesting that up-regulation of FGF3 may play an important role in HCC metastasis and recurrence. © 2006 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectFGF3-
dc.subjectHepatocellular carcinoma-
dc.subjecthsr-
dc.subjectMetastasis-
dc.subjectRecurrence-
dc.subject.meshBlotting, Northernen_HK
dc.subject.meshCarcinoma, Hepatocellular - genetics - metabolism - secondaryen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshChromosomes, Human, Pair 11 - geneticsen_HK
dc.subject.meshCyclin Den_HK
dc.subject.meshCyclins - analysis - genetics - metabolismen_HK
dc.subject.meshFibroblast Growth Factor 3 - analysis - genetics - metabolismen_HK
dc.subject.meshGene Expressionen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLiver Neoplasms - genetics - metabolism - pathologyen_HK
dc.subject.meshMultigene Family - geneticsen_HK
dc.subject.meshRecurrenceen_HK
dc.subject.meshTissue Array Analysisen_HK
dc.subject.meshUp-Regulationen_HK
dc.titleUp-regulation of fibroblast growth factor 3 is associated with tumor metastasis and recurrence in human hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=252&spage=36&epage=42&date=2007&atitle=Up-regulation+of+fibroblast+growth+factor+3+is+associated+with+tumor+metastasis+and+recurrence+in+human+hepatocellular+carcinoma.en_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2006.12.003en_HK
dc.identifier.pmid17215076-
dc.identifier.scopuseid_2-s2.0-34248403730en_HK
dc.identifier.hkuros138964en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34248403730&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume252en_HK
dc.identifier.issue1en_HK
dc.identifier.spage36en_HK
dc.identifier.epage42en_HK
dc.identifier.isiWOS:000247457600004-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridHu, L=34770075600en_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridWen, JM=7402701931en_HK
dc.identifier.scopusauthoridWang, WS=36488756900en_HK
dc.identifier.scopusauthoridWang, Y=7601486269en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.issnl0304-3835-

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