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Conference Paper: Immune response during immunoclearance phase of Chinese patients with HBV genotypes B and C
Title | Immune response during immunoclearance phase of Chinese patients with HBV genotypes B and C |
---|---|
Authors | |
Issue Date | 2005 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep |
Citation | The 40th Annual Meeting of The European Association for the Study of the Liver, Paris, France, 13-17 April 2005. In Journal of Hepatology, 2005, v. 42 suppl. 2, p. 152, abstract no. 416 How to Cite? |
Abstract | Background: Chronic hepatitis B patients with genotype B achieve
HBeAg seroconversion at an earlier age compared with those with genotype
C (Yuen et al., Hepatology 2003). Whether this is due to differences in
tile immune response to file hepatitis B virus during the imrnunoclearance
phase between patients with genotypes B and C has never been studied.
Aims: To compare the immune response during the immunoclearance
phase of patients with genotypes B and C.
Patients and Methods: 20 HBeAg-positive patients with elevated ALT
levels, 10 with genotype B and 10 with genotype C, were recruited. Proliferation
and Till and Th2 immune responses of peripheral blood mononuclear
cells were measured by 3H-thymidine uptake and ELISPOT assays
respectively. The core promoter and precore mutations and HBV DNA
levels were determined.
Results: The followings are the interim results of first 12 patients (4 and 8
with genotypes B and C respectively). P values were not calculated because
of the anlall number of patients. There were no differences in ALT and
HBV DNA levels between two groups. Four patients with genotype B
and 4 patients with genotype C had precore and core promoter mutations
respectively. Compared to patients with genotype C, patients with genotype
B had a higher stimulation index (proliferative response) towards
HBcAg (4.6 vs. 2.7 respectively) and HBeAg (1.9 vs. 1.6 respectively).
The results of tile ELISPOT assays are listed in the table. Conclusions: Compared to patients with genotype B, patients with genotype
C have a lower proliferative response and greater induction of IL-10
production towards HBcAg and HBeAg. These phenomena may explain
the delayed HBeAg seroconversion in patients with genotype C. |
Persistent Identifier | http://hdl.handle.net/10722/77228 |
ISSN | 2021 Impact Factor: 30.083 2020 SCImago Journal Rankings: 7.112 |
DC Field | Value | Language |
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dc.contributor.author | Yuen, RMF | en_HK |
dc.contributor.author | Wong, DKH | en_HK |
dc.contributor.author | Chan, CCS | en_HK |
dc.contributor.author | Zheng, BJ | en_HK |
dc.contributor.author | Yuen, JCH | en_HK |
dc.contributor.author | Lai, CL | en_HK |
dc.date.accessioned | 2010-09-06T07:29:38Z | - |
dc.date.available | 2010-09-06T07:29:38Z | - |
dc.date.issued | 2005 | en_HK |
dc.identifier.citation | The 40th Annual Meeting of The European Association for the Study of the Liver, Paris, France, 13-17 April 2005. In Journal of Hepatology, 2005, v. 42 suppl. 2, p. 152, abstract no. 416 | en_HK |
dc.identifier.issn | 0168-8278 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/77228 | - |
dc.description.abstract | Background: Chronic hepatitis B patients with genotype B achieve HBeAg seroconversion at an earlier age compared with those with genotype C (Yuen et al., Hepatology 2003). Whether this is due to differences in tile immune response to file hepatitis B virus during the imrnunoclearance phase between patients with genotypes B and C has never been studied. Aims: To compare the immune response during the immunoclearance phase of patients with genotypes B and C. Patients and Methods: 20 HBeAg-positive patients with elevated ALT levels, 10 with genotype B and 10 with genotype C, were recruited. Proliferation and Till and Th2 immune responses of peripheral blood mononuclear cells were measured by 3H-thymidine uptake and ELISPOT assays respectively. The core promoter and precore mutations and HBV DNA levels were determined. Results: The followings are the interim results of first 12 patients (4 and 8 with genotypes B and C respectively). P values were not calculated because of the anlall number of patients. There were no differences in ALT and HBV DNA levels between two groups. Four patients with genotype B and 4 patients with genotype C had precore and core promoter mutations respectively. Compared to patients with genotype C, patients with genotype B had a higher stimulation index (proliferative response) towards HBcAg (4.6 vs. 2.7 respectively) and HBeAg (1.9 vs. 1.6 respectively). The results of tile ELISPOT assays are listed in the table. Conclusions: Compared to patients with genotype B, patients with genotype C have a lower proliferative response and greater induction of IL-10 production towards HBcAg and HBeAg. These phenomena may explain the delayed HBeAg seroconversion in patients with genotype C. | - |
dc.language | eng | en_HK |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep | en_HK |
dc.relation.ispartof | Journal of Hepatology | en_HK |
dc.rights | Journal of Hepatology. Copyright © Elsevier BV. | en_HK |
dc.title | Immune response during immunoclearance phase of Chinese patients with HBV genotypes B and C | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-8278&volume=42 &issue=Suppl 2&spage=152&epage=&date=2005&atitle=Immune+Response+During+Immunoclearance+Phase+of+Chinese+Patients+with+HBV+Genotypes+B+and+C | en_HK |
dc.identifier.email | Yuen, RMF: mfyuen@hkucc.hku.hk | en_HK |
dc.identifier.email | Wong, DKH: danwong@hkusua.hku.hk | en_HK |
dc.identifier.email | Chan, CCS: cschan@hkucc.hku.hk | en_HK |
dc.identifier.email | Zheng, BJ: bzheng@hkucc.hku.hk, gpzheng@hkucc.hku.hk | en_HK |
dc.identifier.email | Yuen, JCH: jchyuen@HKUCC.hku.hk | en_HK |
dc.identifier.email | Lai, CL: hrmelcl@hku.hk | en_HK |
dc.identifier.authority | Yuen, RMF=rp00479 | en_HK |
dc.identifier.authority | Wong, DKH=rp00492 | en_HK |
dc.identifier.authority | Zheng, BJ=rp00353 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0168-8278(05)81828-8 | - |
dc.identifier.hkuros | 98466 | en_HK |
dc.identifier.hkuros | 122632 | - |
dc.identifier.volume | 42 | - |
dc.identifier.issue | suppl. 2 | - |
dc.identifier.spage | 152, abstract no. 416 | - |
dc.identifier.epage | 152, abstract no. 416 | - |
dc.publisher.place | The Netherlands | - |
dc.description.other | The 40th Annual Meeting of The European Association for the Study of the Liver, Paris, France, 13-17 April 2005 . In Journal of Hepatology, 2005, v. 42 n. Suppl. 2, p. 152, poster abstract no. 416 | - |
dc.identifier.issnl | 0168-8278 | - |