In vitro primary study of an injectable and fast setting calcium phosphate based biomaterials

Abstract

Because of the similarity to the mineral phase of bone and the nature of set in situ, calcium phosphate bone cement has been regarded as promising materials to realize minimal invasive surgery for bone defect repair. In present study, by optimizing the composition of the materials, an injectable and fast setting calcium phosphate-based biomaterials (IFCP) has been made. The injectable time from a needle and the setting time and the setting temperature were tested. The results showed the materials could be used as injectable and shaped in situ materials. The setting reaction of the materials and the effects of some additives to the setting reactions are also studied. Due to its main composite of calcium phosphate with amorophous crystalline structure, the materials may have good bioactivity and may be a promising substance for bone defect reconstruction with minimal invasive surgery. Further studies are proceeding.