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Conference Paper: Detection of gray matter damage in neonatal rat model of mild hypoxic-ischemic insult by manganese-enhanced MRI
| Title | Detection of gray matter damage in neonatal rat model of mild hypoxic-ischemic insult by manganese-enhanced MRI |
|---|---|
| Authors | |
| Issue Date | 2007 |
| Publisher | International Society for Magnetic Resonance in Medicine |
| Citation | Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany, 19-25 May 2007. In 2007 Scientific Meeting Proceedings, 2007, p. 594 Abstract no. 3083 How to Cite? |
| Abstract | This study aims to use manganese-enhanced MRI (MEMRI) to investigate the progression and permanence of the gray matter injuries in a neonatal rat
model of relatively selective white matter injury induced by mild H-I insult. The transient changes associated with gray matter injuries in the neonatal model
of mild H-I insult were shown to be enhanced by systemic Mn2+ administration from 3rd day up to 21th day after hypoxic-ischemic insult. Such Mn
enhancement paradigm may be potentially useful in detecting the gray matter injuries in late phase of neonatal models of selective white matter injuries that
are not visible in the conventional T1-weighted image, T2-weighted image and diffusion weighted image. |
| Persistent Identifier | http://hdl.handle.net/10722/99521 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Yang, J | en_HK |
| dc.contributor.author | Wu, EX | en_HK |
| dc.date.accessioned | 2010-09-25T18:33:49Z | - |
| dc.date.available | 2010-09-25T18:33:49Z | - |
| dc.date.issued | 2007 | en_HK |
| dc.identifier.citation | Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany, 19-25 May 2007. In 2007 Scientific Meeting Proceedings, 2007, p. 594 Abstract no. 3083 | en_HK |
| dc.identifier.uri | http://hdl.handle.net/10722/99521 | - |
| dc.description.abstract | This study aims to use manganese-enhanced MRI (MEMRI) to investigate the progression and permanence of the gray matter injuries in a neonatal rat model of relatively selective white matter injury induced by mild H-I insult. The transient changes associated with gray matter injuries in the neonatal model of mild H-I insult were shown to be enhanced by systemic Mn2+ administration from 3rd day up to 21th day after hypoxic-ischemic insult. Such Mn enhancement paradigm may be potentially useful in detecting the gray matter injuries in late phase of neonatal models of selective white matter injuries that are not visible in the conventional T1-weighted image, T2-weighted image and diffusion weighted image. | - |
| dc.language | eng | en_HK |
| dc.publisher | International Society for Magnetic Resonance in Medicine | - |
| dc.relation.ispartof | Joint Annual Meeting ISMRM-ESMRMB | en_HK |
| dc.title | Detection of gray matter damage in neonatal rat model of mild hypoxic-ischemic insult by manganese-enhanced MRI | en_HK |
| dc.type | Conference_Paper | en_HK |
| dc.identifier.email | Wu, EX: ewu@eee.hku.hk | en_HK |
| dc.identifier.authority | Wu, EX=rp00193 | en_HK |
| dc.identifier.hkuros | 132157 | en_HK |
| dc.identifier.hkuros | 141502 | - |
| dc.customcontrol.immutable | sml 160114 - merged | - |