Klf4 interacts with PCG-1/ERR to regulate mitochondrial biogenesis and dynamics in rescuing complex I dysfunction-provoked mesenchymal stem cell ageing

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Grant Data
Project Title
Klf4 interacts with PCG-1/ERR to regulate mitochondrial biogenesis and dynamics in rescuing complex I dysfunction-provoked mesenchymal stem cell ageing
Principal Investigator
Professor Tse, Hung Fat   (Principal Investigator (PI))
Co-Investigator(s)
Dr Yan Bin   (Co-Investigator)
Dr Lian Qizhou   (Co-Investigator)
Duration
36
Start Date
2017-09-01
Amount
928200
Conference Title
Klf4 interacts with PCG-1/ERR to regulate mitochondrial biogenesis and dynamics in rescuing complex I dysfunction-provoked mesenchymal stem cell ageing
Presentation Title
Keywords
Klf4, mesenchymal stem cell ageing, mitochondrial biogenesis, mitochondrial dynamics, mitochondrial dysfunction
Discipline
Stem Cell Biology,Cell Biology
Panel
Biology and Medicine (M)
HKU Project Code
17120517
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To characterize the role of Klf4 in mitochondrial biogenesis and dynamics in mitochondrial complex I defect-provoked mesenchymal stem cell ageing 2 To elucidate interactions of Klf4 and PPARĪ³ coactivator 1 in regulating mitochondrial biogenesis and dynamics in vitro defect-provoked mesenchymal stem cells ageing 3 To examine functional rescuing of mesenchymal stem cell ageing by modulating Klf4-PPARĪ³ coactivator 1 in complex I deficiency mouse models