Identification and characterization of C11ORF86, a novel CREBH target gene implicated in hypertriglyceridemia
Grant Data
Project Title
Identification and characterization of C11ORF86, a novel CREBH target gene implicated in hypertriglyceridemia
Principal Investigator
Dr Cheng, Yun
(Principal Investigator (PI))
Co-Investigator(s)
Dr Tipoe George Lim
(Co-Investigator)
Dr Chan Chi Ping
(Co-Investigator)
Dr Ye Ziwei
(Co-Investigator)
Duration
32
Start Date
2018-09-01
Amount
1084048
Conference Title
Identification and characterization of C11ORF86, a novel CREBH target gene implicated in hypertriglyceridemia
Presentation Title
Keywords
C11ORF86, CREBH, Fasting, Hypertriglyceridemi, Lipid metabolism, PPAR family
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
05163786
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2017
Status
Completed
Objectives
First, we will characterize the basic biochemical properties of C11ORF86, including its expression pattern, subcelluar localization, protein interaction partners and posttranslational modifications. Then we will explore the upstream signals and pathways that induce C11ORF86 expression, mainly including fasting-induced PKA-CREBH and PPARα/PGC1α pathways. Furthermore, we will define the anti-hypertriglyceridemic effects of C11ORF86 and its impact on steotosis. Finally, we will investigate the mechinam by which C11ORF86 lowers blood TG.