P-cadherin: a critical mediator of niche activation, metabolic coupling, and metastatic colonization?
Grant Data
Project Title
P-cadherin: a critical mediator of niche activation, metabolic coupling, and metastatic colonization?
Principal Investigator
Professor Wong, Alice Sze Tsai
(Principal Investigator (PI))
Co-Investigator(s)
Professor Cheung Annie Nga Yin
(Co-Investigator)
Professor Wong Carmen Chak Lui
(Co-Investigator)
Professor Chan Chi Bun
(Co-Investigator)
Duration
36
Start Date
2020-01-01
Completion Date
2022-12-31
Amount
1044215
Conference Title
P-cadherin: a critical mediator of niche activation, metabolic coupling, and metastatic colonization?
Keywords
adhesion, functional roles of genes, progression
Discipline
Molecular Biology
Panel
Biology and Medicine (M)
HKU Project Code
17105919
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 To elucidate the specific contribution of P-cadherin-driven HM on niche activation and how the crosstalk may affect tumorigenic behavior 2 To decipher the molecular mechanism of metabolic coupling, with particular reference to glycolysis and lipogenesis 3 To unravel the underlying mechanisms of action of P-cadherin-driven metastatic colonization