SARS-CoV2 infection dynamics in bat and human cells: tissue tropism and differential host response for elucidation of evolutionary pathway and exploration of potential treatment targets
Grant Data
Project Title
SARS-CoV2 infection dynamics in bat and human cells: tissue tropism and differential host response for elucidation of evolutionary pathway and exploration of potential treatment targets
Principal Investigator
Dr Luk, Kam Hei
(Principal Investigator (PI))
Co-Investigator(s)
Professor Woo Patrick Chiu Yat
(Co-Investigator)
Dr Chow Wang Ngai
(Co-Investigator)
Dr Li Kenneth Sze Ming
(Co-Investigator)
Duration
24
Start Date
2020-05-01
Completion Date
2024-09-17
Amount
2998583
Conference Title
SARS-CoV2 infection dynamics in bat and human cells: tissue tropism and differential host response for elucidation of evolutionary pathway and exploration of potential treatment targets
Keywords
elucidation of evolutionary pathway, SARS-CoV2 infection, tissue tropism, treatment
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
COVID190122
Grant Type
Commissioned Research on the Novel Coronavirus Disease (COVID-19)
Funding Year
2019
Status
Completed
Objectives
To elucidate the evolutionary origin and pathway of SARS-CoV-2 and understand its immunopathogenesis in bats and humans, we aim to (1) study the susceptibilities and tropism of SARS-CoV-2 to bat cell lines from different bat species; (2) study the viral replication kinetics of SARS-CoV-2 in susceptible bat and human cells; (3) study the role of bat ACE2 expression in SARS-CoV-2 replication in bat cells and (4) study the changes in gene expression profiles of bats cells infected by SARS-CoV-2 compared to human cells.