Kepler-Poinsot DNA nanostructures as Sharp Next-Generation Drug Delivery Vehicles
Grant Data
Project Title
Kepler-Poinsot DNA nanostructures as Sharp Next-Generation Drug Delivery Vehicles
Principal Investigator
Professor Tanner, Julian Alexander
(Principal Investigator (PI))
Duration
42
Start Date
2021-11-01
Amount
1046932
Conference Title
Kepler-Poinsot DNA nanostructures as Sharp Next-Generation Drug Delivery Vehicles
Keywords
aptamer, DNA, nanostructure, nanotechnology, nucleic acid
Discipline
Molecular BiologyDrug Discovery and Delivery
Panel
Biology and Medicine (M)
HKU Project Code
17125221
Grant Type
General Research Fund (GRF)
Funding Year
2021
Status
On-going
Objectives
1 Investigate the factors which control the formation of facet-based smooth Platonic and sharp Kepler-Poinsot DNA polyhedra 2 Determine the relative gold nanoparticle and doxorubicin loading capability of the Platonic and Kepler-Poinsot polyhedra 3 Compare the rigidity and robustness of the four facet-based polyhedra relative to origami-based and tile-based polyhedra 4 Determine the relative abilities of Platonic and Kepler-Poinsot polyhedra in cell entry and cellular fate 5 Compare Platonic and Kepler-Poinsot polyhedra in targeted delivery, antitumour activity, and toxicity in a xenograft mouse study