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- Publisher Website: 10.1016/0020-711X(82)90113-6
- Scopus: eid_2-s2.0-0020264362
- PMID: 7106347
- WOS: WOS:A1982NV64500005
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Article: Chemical modification of hemoglobin in intact whole cells: Morphological studies by scanning electron microscope
Title | Chemical modification of hemoglobin in intact whole cells: Morphological studies by scanning electron microscope |
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Authors | |
Issue Date | 1982 |
Citation | International Journal Of Biochemistry, 1982, v. 14 n. 6, p. 461-465 How to Cite? |
Abstract | Whole blood was incubated in physiological conditions with a variety of modifiers capable of modifying hemoglobin. Some of these compounds have been considered as therapeutic agents for certain hemoglobinopathies such as sickle-cell disease. The extent of modification on hemoglobin was estimated by electrophoresis and the red-cell morphology by scanning electron microscope. Results indicated that carbamyl phosphate, aspirin and glutaryl-salicylamide had no observable effect, whereas cross-linkers in general produced drastic changes in red-cell morphology. Dibromoaspirin, a very effective acetylating agent, produced abnormalities even in concentrations as low as 1 mM. |
Persistent Identifier | http://hdl.handle.net/10722/147304 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cheng, LYL | en_US |
dc.contributor.author | Tam, JWO | en_US |
dc.date.accessioned | 2012-05-29T06:02:48Z | - |
dc.date.available | 2012-05-29T06:02:48Z | - |
dc.date.issued | 1982 | en_US |
dc.identifier.citation | International Journal Of Biochemistry, 1982, v. 14 n. 6, p. 461-465 | en_US |
dc.identifier.issn | 0020-711X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/147304 | - |
dc.description.abstract | Whole blood was incubated in physiological conditions with a variety of modifiers capable of modifying hemoglobin. Some of these compounds have been considered as therapeutic agents for certain hemoglobinopathies such as sickle-cell disease. The extent of modification on hemoglobin was estimated by electrophoresis and the red-cell morphology by scanning electron microscope. Results indicated that carbamyl phosphate, aspirin and glutaryl-salicylamide had no observable effect, whereas cross-linkers in general produced drastic changes in red-cell morphology. Dibromoaspirin, a very effective acetylating agent, produced abnormalities even in concentrations as low as 1 mM. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | International Journal of Biochemistry | en_US |
dc.subject.mesh | Anemia, Sickle Cell - Blood | en_US |
dc.subject.mesh | Erythrocytes - Drug Effects - Ultrastructure | en_US |
dc.subject.mesh | Hemoglobins, Abnormal - Metabolism | en_US |
dc.subject.mesh | Hemolysis - Drug Effects | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Microscopy, Electron, Scanning | en_US |
dc.title | Chemical modification of hemoglobin in intact whole cells: Morphological studies by scanning electron microscope | en_US |
dc.type | Article | en_US |
dc.identifier.email | Cheng, LYL:lcheng@hkucc.hku.hk | en_US |
dc.identifier.authority | Cheng, LYL=rp00317 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0020-711X(82)90113-6 | - |
dc.identifier.pmid | 7106347 | en_US |
dc.identifier.scopus | eid_2-s2.0-0020264362 | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 461 | en_US |
dc.identifier.epage | 465 | en_US |
dc.identifier.isi | WOS:A1982NV64500005 | - |
dc.identifier.scopusauthorid | Cheng, LYL=7403337122 | en_US |
dc.identifier.scopusauthorid | Tam, JWO=7102534616 | en_US |
dc.identifier.issnl | 0020-711X | - |