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Conference Paper: PHBV tissue engineering scaffolds fabricated via emulsion freezing / freeze-drying: effects of processing parameters
Title | PHBV tissue engineering scaffolds fabricated via emulsion freezing / freeze-drying: effects of processing parameters |
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Authors | |
Keywords | Scaffolds Tissue engineering Emulsion freezing Freeze-drying PHBV |
Issue Date | 2011 |
Publisher | International Proceedings of Chemical, Biological and Environmental Engineering. The Journal's web site is located at http://www.ipcbee.com/proceeding.htm |
Citation | The 2011 International Conference on Biomedical Engineering and Technology ( ICBET 2011), Kuala Lumpur, Malaysia, 4-5 June 2011. In IPCBEE Proceedings, v. 11, p. 29-34 How to Cite? |
Abstract | Biodegradable polymers have been widely used for scaffolds in tissue engineering which aims to form completely natural tissues without leaving permanently synthetic element(s) in the human body. Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a natural, biocompatible and biodegradable polymer suitable for tissue engineering applications. This paper reports the fabrication and characterization of three dimensional, highly porous PHBV scaffolds produced through the emulsion freezing/freeze-drying technique. PHBV emulsions having 2.5%, 5%, 7.5%, 10%, 12.5% (w/v) PHBV concentrations were used. Freezing and freeze-drying of polymer/solvent/water phase emulsions produced hard and tough scaffolds with interconnected pores having good handling quality. The porosity of scaffolds changed from 85% to 71% when the PHBV concentration in emulsions increased from 2.5% to 12.5%. Compressive mechanical properties of scaffolds were increased with increasing PHBV concentration. The scaffolds had pore sizes ranging from several microns to a few hundred microns. |
Description | Open Access Journal |
Persistent Identifier | http://hdl.handle.net/10722/165375 |
ISSN |
DC Field | Value | Language |
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dc.contributor.author | Sultana, N | en_US |
dc.contributor.author | Wang, M | en_US |
dc.date.accessioned | 2012-09-20T08:17:47Z | - |
dc.date.available | 2012-09-20T08:17:47Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | The 2011 International Conference on Biomedical Engineering and Technology ( ICBET 2011), Kuala Lumpur, Malaysia, 4-5 June 2011. In IPCBEE Proceedings, v. 11, p. 29-34 | en_US |
dc.identifier.issn | 2010-4618 | - |
dc.identifier.uri | http://hdl.handle.net/10722/165375 | - |
dc.description | Open Access Journal | - |
dc.description.abstract | Biodegradable polymers have been widely used for scaffolds in tissue engineering which aims to form completely natural tissues without leaving permanently synthetic element(s) in the human body. Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a natural, biocompatible and biodegradable polymer suitable for tissue engineering applications. This paper reports the fabrication and characterization of three dimensional, highly porous PHBV scaffolds produced through the emulsion freezing/freeze-drying technique. PHBV emulsions having 2.5%, 5%, 7.5%, 10%, 12.5% (w/v) PHBV concentrations were used. Freezing and freeze-drying of polymer/solvent/water phase emulsions produced hard and tough scaffolds with interconnected pores having good handling quality. The porosity of scaffolds changed from 85% to 71% when the PHBV concentration in emulsions increased from 2.5% to 12.5%. Compressive mechanical properties of scaffolds were increased with increasing PHBV concentration. The scaffolds had pore sizes ranging from several microns to a few hundred microns. | - |
dc.language | eng | en_US |
dc.publisher | International Proceedings of Chemical, Biological and Environmental Engineering. The Journal's web site is located at http://www.ipcbee.com/proceeding.htm | - |
dc.relation.ispartof | IPCBEE Proceedings | en_US |
dc.subject | Scaffolds | - |
dc.subject | Tissue engineering | - |
dc.subject | Emulsion freezing | - |
dc.subject | Freeze-drying | - |
dc.subject | PHBV | - |
dc.title | PHBV tissue engineering scaffolds fabricated via emulsion freezing / freeze-drying: effects of processing parameters | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Sultana, N: naznin@utm.my | en_US |
dc.identifier.email | Wang, M: memwang@hku.hk | - |
dc.identifier.authority | Wang, M=rp00185 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 207611 | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.spage | 29 | en_US |
dc.identifier.epage | 34 | en_US |
dc.publisher.place | Singapore | - |
dc.description.other | The 2011 International Conference on Biomedical Engineering and Technology ( ICBET 2011), Kuala Lumpur, Malaysia, 4-5 June 2011. In IPCBEE Proceedings, v. 11, p. 29-34 | - |
dc.identifier.issnl | 2010-4618 | - |