File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/0014-4827(82)90421-9
- Scopus: eid_2-s2.0-0020446420
- PMID: 6291963
- WOS: WOS:A1982PS24800020
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Loss and restoration of glucagon receptors and responsiveness in a transformed kidney cell line
Title | Loss and restoration of glucagon receptors and responsiveness in a transformed kidney cell line |
---|---|
Authors | |
Issue Date | 1982 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexcr |
Citation | Experimental Cell Research, 1982, v. 142 n. 1, p. 181-189 How to Cite? |
Abstract | A kidney cell line (MDCK) retains an adenylate cyclase system sensitive to glucagon, vasopressin, isoproterenol and prostaglandin E1. The stimulatory effect of glucagon on cAMP production was selectively lost in a cloned line derived from MDCK cells transformed by Harvey murine sarcoma virus. Sensitivity to glucagon was largely restored by treatment of the transformed cells with prostaglandin E1 or butyrate. Loss and reappearance of glucagon receptors seemed to be responsible for the observation. The parental MDCK line produced prostaglandins and in the transformed line, this function was abolished. These observations suggest that synthesis of glucagon receptors is controlled by endogenously produced prostaglandin in MDCK cells and that loss of glucagon receptors and their responsiveness in the transformed cells occurs as a consequence of the inability of these cells to synthesize this prostaglandin. |
Persistent Identifier | http://hdl.handle.net/10722/167455 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 0.947 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lin, MC | en_US |
dc.contributor.author | Koh, SWM | en_US |
dc.contributor.author | Dykman, DD | en_US |
dc.date.accessioned | 2012-10-08T03:07:13Z | - |
dc.date.available | 2012-10-08T03:07:13Z | - |
dc.date.issued | 1982 | en_US |
dc.identifier.citation | Experimental Cell Research, 1982, v. 142 n. 1, p. 181-189 | en_US |
dc.identifier.issn | 0014-4827 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/167455 | - |
dc.description.abstract | A kidney cell line (MDCK) retains an adenylate cyclase system sensitive to glucagon, vasopressin, isoproterenol and prostaglandin E1. The stimulatory effect of glucagon on cAMP production was selectively lost in a cloned line derived from MDCK cells transformed by Harvey murine sarcoma virus. Sensitivity to glucagon was largely restored by treatment of the transformed cells with prostaglandin E1 or butyrate. Loss and reappearance of glucagon receptors seemed to be responsible for the observation. The parental MDCK line produced prostaglandins and in the transformed line, this function was abolished. These observations suggest that synthesis of glucagon receptors is controlled by endogenously produced prostaglandin in MDCK cells and that loss of glucagon receptors and their responsiveness in the transformed cells occurs as a consequence of the inability of these cells to synthesize this prostaglandin. | - |
dc.language | eng | en_US |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexcr | en_US |
dc.relation.ispartof | Experimental Cell Research | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Butyric Acids - Pharmacology | en_US |
dc.subject.mesh | Cell Line | en_US |
dc.subject.mesh | Cell Membrane - Metabolism | en_US |
dc.subject.mesh | Cell Transformation, Viral | en_US |
dc.subject.mesh | Cyclic Amp - Biosynthesis | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Kidney | en_US |
dc.subject.mesh | Prostaglandins E - Metabolism - Pharmacology | en_US |
dc.subject.mesh | Prostaglandins F - Metabolism | en_US |
dc.subject.mesh | Receptors, Cell Surface - Metabolism | en_US |
dc.subject.mesh | Receptors, Glucagon | en_US |
dc.subject.mesh | Sarcoma Viruses, Murine | en_US |
dc.title | Loss and restoration of glucagon receptors and responsiveness in a transformed kidney cell line | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lin, MC:mcllin@hkucc.hku.hk | en_US |
dc.identifier.authority | Lin, MC=rp00746 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0014-4827(82)90421-9 | - |
dc.identifier.pmid | 6291963 | - |
dc.identifier.scopus | eid_2-s2.0-0020446420 | en_US |
dc.identifier.volume | 142 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 181 | en_US |
dc.identifier.epage | 189 | en_US |
dc.identifier.isi | WOS:A1982PS24800020 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lin, MC=7404816359 | en_US |
dc.identifier.scopusauthorid | Koh, SWM=7202062547 | en_US |
dc.identifier.scopusauthorid | Dykman, DD=55300521600 | en_US |
dc.identifier.issnl | 0014-4827 | - |