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- Publisher Website: 10.1016/j.jacc.2003.08.030
- Scopus: eid_2-s2.0-0347683345
- PMID: 14715193
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Article: Novel and Traditional Cardiovascular Risk Factors in Children after Kawasaki Disease: Implications for Premature Atherosclerosis
Title | Novel and Traditional Cardiovascular Risk Factors in Children after Kawasaki Disease: Implications for Premature Atherosclerosis |
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Authors | |
Issue Date | 2004 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac |
Citation | Journal Of The American College Of Cardiology, 2004, v. 43 n. 1, p. 120-124 How to Cite? |
Abstract | OBJECTIVES: We determined the profile of cardiovascular risk factors in children late after Kawasaki disease (KD) and compared it with that of age-matched healthy children. BACKGROUND: Concerns have been raised regarding the possibility of a predisposition of KD to premature atherosclerosis later in life. METHODS: A cohort of 102 subjects were studied: 37 KD patients with coronary aneurysms (group I), 29 KD patients with normal coronary arteries (group II), and 36 healthy age-matched children (group III). The fasting total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein (apo) A-I, apoB, and homocysteine levels were compared among the three groups. In addition, blood pressure and brachioradial arterial stiffness, as determined by pulse wave velocity (PWV), were measured and compared. RESULTS: Group I subjects had lower HDL cholesterol (p = 0.016) and apoA-I levels (p = 0.044) and higher apoB levels (p = 0.029) and PWV (p = 0.001) than group III control subjects. Likewise, the apoB levels (p = 0.007) and PWV (p = 0.042) were higher in group II than in III subjects, although their HDL cholesterol (p = 0.54) and apoA-I (p = 0.52) levels were similar. The LDL cholesterol levels were higher in group I and II patients than in controls, although not statistically significant (p = 0.17). Blood pressure and homocysteine levels did not differ among the groups. CONCLUSIONS: An adverse cardiovascular risk profile, as characterized by a proatherogenic alteration of the lipid profile and increased arterial stiffness, occurs in children after KD. The profile is worse in those with than in those without coronary aneurysms. © 2004 by the American College of Cardiology Foundation. |
Persistent Identifier | http://hdl.handle.net/10722/170335 |
ISSN | 2021 Impact Factor: 27.203 2020 SCImago Journal Rankings: 10.315 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Cheung, YF | en_US |
dc.contributor.author | Yung, TC | en_US |
dc.contributor.author | Tam, SCF | en_US |
dc.contributor.author | Ho, MHK | en_US |
dc.contributor.author | Chau, AKT | en_US |
dc.date.accessioned | 2012-10-30T06:07:34Z | - |
dc.date.available | 2012-10-30T06:07:34Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Journal Of The American College Of Cardiology, 2004, v. 43 n. 1, p. 120-124 | en_US |
dc.identifier.issn | 0735-1097 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170335 | - |
dc.description.abstract | OBJECTIVES: We determined the profile of cardiovascular risk factors in children late after Kawasaki disease (KD) and compared it with that of age-matched healthy children. BACKGROUND: Concerns have been raised regarding the possibility of a predisposition of KD to premature atherosclerosis later in life. METHODS: A cohort of 102 subjects were studied: 37 KD patients with coronary aneurysms (group I), 29 KD patients with normal coronary arteries (group II), and 36 healthy age-matched children (group III). The fasting total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein (apo) A-I, apoB, and homocysteine levels were compared among the three groups. In addition, blood pressure and brachioradial arterial stiffness, as determined by pulse wave velocity (PWV), were measured and compared. RESULTS: Group I subjects had lower HDL cholesterol (p = 0.016) and apoA-I levels (p = 0.044) and higher apoB levels (p = 0.029) and PWV (p = 0.001) than group III control subjects. Likewise, the apoB levels (p = 0.007) and PWV (p = 0.042) were higher in group II than in III subjects, although their HDL cholesterol (p = 0.54) and apoA-I (p = 0.52) levels were similar. The LDL cholesterol levels were higher in group I and II patients than in controls, although not statistically significant (p = 0.17). Blood pressure and homocysteine levels did not differ among the groups. CONCLUSIONS: An adverse cardiovascular risk profile, as characterized by a proatherogenic alteration of the lipid profile and increased arterial stiffness, occurs in children after KD. The profile is worse in those with than in those without coronary aneurysms. © 2004 by the American College of Cardiology Foundation. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac | en_US |
dc.relation.ispartof | Journal of the American College of Cardiology | en_US |
dc.subject.mesh | Cardiovascular Diseases - Blood - Epidemiology - Etiology | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Cholesterol, Hdl - Blood | en_US |
dc.subject.mesh | Cholesterol, Ldl - Blood | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mucocutaneous Lymph Node Syndrome - Blood - Complications | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.title | Novel and Traditional Cardiovascular Risk Factors in Children after Kawasaki Disease: Implications for Premature Atherosclerosis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Cheung, YF:xfcheung@hku.hk | en_US |
dc.identifier.authority | Cheung, YF=rp00382 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.jacc.2003.08.030 | en_US |
dc.identifier.pmid | 14715193 | - |
dc.identifier.scopus | eid_2-s2.0-0347683345 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0347683345&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 43 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 120 | en_US |
dc.identifier.epage | 124 | en_US |
dc.identifier.isi | WOS:000187795400022 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Cheung, YF=7202111067 | en_US |
dc.identifier.scopusauthorid | Yung, TC=9132842300 | en_US |
dc.identifier.scopusauthorid | Tam, SCF=7202037323 | en_US |
dc.identifier.scopusauthorid | Ho, MHK=8925896400 | en_US |
dc.identifier.scopusauthorid | Chau, AKT=35787094400 | en_US |
dc.identifier.issnl | 0735-1097 | - |