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- Publisher Website: 10.1097/00005344-198500076-00009
- Scopus: eid_2-s2.0-0022219720
- PMID: 2414595
- WOS: WOS:A1985ANY3200009
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Article: Lipoxygenase and calcium entry in vascular smooth muscle
Title | Lipoxygenase and calcium entry in vascular smooth muscle |
---|---|
Authors | |
Keywords | Calcium entry Lipoxygenase Vascular smooth muscle |
Issue Date | 1985 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ |
Citation | Journal Of Cardiovascular Pharmacology, 1985, v. 7 SUPPL. 6, p. S47-S52 How to Cite? |
Abstract | In the canine saphenous vein, inhibitors of cyclo-oxygenase augment contractile responses to acetylcholine, potassium chloride and partial α-adrenergic activation. This augmentation is prevented by inhibitors of lipoxygenase, and abolished by calcium entry blockers. These observations suggest that when Ca2+ enters the smooth muscle cells it activates the metabolism of arachidonic acid. If cyclo-oxygenase is inhibited, end-products of lipoxygenase exert a positive feedback on calcium entry. A similar mechanism may explain the hypoxic contractions observed in various blood vessels, including coronary arteries. |
Persistent Identifier | http://hdl.handle.net/10722/170789 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Rimele, TJ | en_US |
dc.contributor.author | Flavahan, NA | en_US |
dc.date.accessioned | 2012-10-30T06:10:52Z | - |
dc.date.available | 2012-10-30T06:10:52Z | - |
dc.date.issued | 1985 | en_US |
dc.identifier.citation | Journal Of Cardiovascular Pharmacology, 1985, v. 7 SUPPL. 6, p. S47-S52 | en_US |
dc.identifier.issn | 0160-2446 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170789 | - |
dc.description.abstract | In the canine saphenous vein, inhibitors of cyclo-oxygenase augment contractile responses to acetylcholine, potassium chloride and partial α-adrenergic activation. This augmentation is prevented by inhibitors of lipoxygenase, and abolished by calcium entry blockers. These observations suggest that when Ca2+ enters the smooth muscle cells it activates the metabolism of arachidonic acid. If cyclo-oxygenase is inhibited, end-products of lipoxygenase exert a positive feedback on calcium entry. A similar mechanism may explain the hypoxic contractions observed in various blood vessels, including coronary arteries. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ | en_US |
dc.relation.ispartof | Journal of Cardiovascular Pharmacology | en_US |
dc.subject | Calcium entry | - |
dc.subject | Lipoxygenase | - |
dc.subject | Vascular smooth muscle | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anoxia - Physiopathology | en_US |
dc.subject.mesh | Arachidonic Acid | en_US |
dc.subject.mesh | Arachidonic Acids - Metabolism | en_US |
dc.subject.mesh | Calcium - Physiology | en_US |
dc.subject.mesh | Calcium Channel Blockers - Pharmacology | en_US |
dc.subject.mesh | Catechols - Pharmacology | en_US |
dc.subject.mesh | Cyclooxygenase Inhibitors | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Epinephrine - Pharmacology | en_US |
dc.subject.mesh | Indomethacin - Pharmacology | en_US |
dc.subject.mesh | Lipoxygenase Inhibitors | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects - Physiology | en_US |
dc.subject.mesh | Nordihydroguaiaretic Acid | en_US |
dc.subject.mesh | Potassium - Pharmacology | en_US |
dc.title | Lipoxygenase and calcium entry in vascular smooth muscle | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1097/00005344-198500076-00009 | - |
dc.identifier.pmid | 2414595 | - |
dc.identifier.scopus | eid_2-s2.0-0022219720 | en_US |
dc.identifier.volume | 7 | en_US |
dc.identifier.issue | SUPPL. 6 | en_US |
dc.identifier.spage | S47 | en_US |
dc.identifier.epage | S52 | en_US |
dc.identifier.isi | WOS:A1985ANY3200009 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | Rimele, TJ=7004614618 | en_US |
dc.identifier.scopusauthorid | Flavahan, NA=7006398882 | en_US |
dc.identifier.issnl | 0160-2446 | - |