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- Publisher Website: 10.1016/0014-2999(90)94803-6
- Scopus: eid_2-s2.0-0025215171
- PMID: 2110066
- WOS: WOS:A1990CW70000017
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Article: Pertussis toxin inhibits endothelium-dependent relaxations evoked by fluoride
Title | Pertussis toxin inhibits endothelium-dependent relaxations evoked by fluoride |
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Authors | |
Keywords | Bacterial toxins EDRF Endothelium-derived relaxing factor G-proteins guanine nucleotide regulatory proteins |
Issue Date | 1990 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar |
Citation | European Journal Of Pharmacology, 1990, v. 178 n. 1, p. 121-124 How to Cite? |
Abstract | Fluoride is a direct activator of G-proteins. In isolated rings of canine coronary artery, fluoride caused relaxation of rings with endothelium, but only slight contraction of rings denuded of endothelium. The endothelium-dependent relaxations to fluoride were inhibited by pertussis toxin, an inhibitor of G-proteins, or by methylene blue, an inhibitor of soluble guanylate cyclase. Therefore, fluoride causes endothelium-dependent relaxations in part by activating a pertussis toxin-sensitive G-protein in the endothelial cells. |
Persistent Identifier | http://hdl.handle.net/10722/170981 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.055 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Flavahan, NA | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:42Z | - |
dc.date.available | 2012-10-30T06:11:42Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | European Journal Of Pharmacology, 1990, v. 178 n. 1, p. 121-124 | en_US |
dc.identifier.issn | 0014-2999 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170981 | - |
dc.description.abstract | Fluoride is a direct activator of G-proteins. In isolated rings of canine coronary artery, fluoride caused relaxation of rings with endothelium, but only slight contraction of rings denuded of endothelium. The endothelium-dependent relaxations to fluoride were inhibited by pertussis toxin, an inhibitor of G-proteins, or by methylene blue, an inhibitor of soluble guanylate cyclase. Therefore, fluoride causes endothelium-dependent relaxations in part by activating a pertussis toxin-sensitive G-protein in the endothelial cells. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar | en_US |
dc.relation.ispartof | European Journal of Pharmacology | en_US |
dc.subject | Bacterial toxins | - |
dc.subject | EDRF | - |
dc.subject | Endothelium-derived relaxing factor | - |
dc.subject | G-proteins | - |
dc.subject | guanine nucleotide regulatory proteins | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Aluminum - Pharmacology | en_US |
dc.subject.mesh | Aluminum Compounds | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Chlorides - Pharmacology | en_US |
dc.subject.mesh | Coronary Vessels - Drug Effects | en_US |
dc.subject.mesh | Dinoprost - Pharmacology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fluorides - Pharmacology | en_US |
dc.subject.mesh | Gtp-Binding Proteins - Pharmacology | en_US |
dc.subject.mesh | Indomethacin - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Methylene Blue - Pharmacology | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle Relaxation - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects | en_US |
dc.subject.mesh | Nitric Oxide - Antagonists & Inhibitors | en_US |
dc.subject.mesh | Nitroglycerin - Pharmacology | en_US |
dc.subject.mesh | Pertussis Toxin | en_US |
dc.subject.mesh | Propranolol - Pharmacology | en_US |
dc.subject.mesh | Virulence Factors, Bordetella - Pharmacology | en_US |
dc.title | Pertussis toxin inhibits endothelium-dependent relaxations evoked by fluoride | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0014-2999(90)94803-6 | - |
dc.identifier.pmid | 2110066 | - |
dc.identifier.scopus | eid_2-s2.0-0025215171 | en_US |
dc.identifier.volume | 178 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 121 | en_US |
dc.identifier.epage | 124 | en_US |
dc.identifier.isi | WOS:A1990CW70000017 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Flavahan, NA=7006398882 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0014-2999 | - |