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- Publisher Website: 10.1007/s11095-010-0332-2
- Scopus: eid_2-s2.0-79955603054
- PMID: 21136142
- WOS: WOS:000288805300011
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Article: Formation of protein nano-matrix particles with controlled surface architecture for respiratory drug delivery
Title | Formation of protein nano-matrix particles with controlled surface architecture for respiratory drug delivery |
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Authors | |
Keywords | aggregates dispersion lysozyme nano-matrix roughness |
Issue Date | 2011 |
Publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741 |
Citation | Pharmaceutical Research, 2011, v. 28 n. 4, p. 788-796 How to Cite? |
Abstract | Purpose: To produce and examine the aerosol performance of protein nano-matrix particles with different surface roughness. Methods: Aqueous lysozyme solutions were poured into isopropanol during high-shear mixing to produce nanoparticles by precipitation. The size of the nanoparticles was varied by adjusting the precipitation conditions. The resultant suspensions were spray-dried to obtain micron-sized aggregates (nano-matrices). Smooth particles were made by spray-drying a lysozyme solution. The aggregate size distribution, surface roughness, and cohesion were evaluated. The aerosol performance was assessed by dispersing 10 mg of powder from a Rotahaler ® at 60 L/min or an Aerolizer® at 100 L/min into a Next Generation Impactor, followed by chemical assay (n∈=∈3). Results: The median volume diameter and span of the nano-matrix particles were 1.0-1.2 μm and 1.5-1.6, respectively, which were comparable to those of the smooth particles. Surface roughness increased with the size of the primary nanoparticles. The nano-matrix particles were significantly less cohesive than the smooth particles. The fine particle fraction increased linearly with increasing surface roughness and decreasing cohesion. Conclusions: Nano-matrix particles with controlled surface architecture were successfully produced by spray-drying nanosuspensions. Aerosol performance was enhanced with increasing surface roughness due to the reduction in cohesion forces. © 2010 Springer Science+Business Media, LLC. |
Persistent Identifier | http://hdl.handle.net/10722/171420 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 0.707 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Kwok, PCL | en_US |
dc.contributor.author | Tunsirikongkon, A | en_US |
dc.contributor.author | Glover, W | en_US |
dc.contributor.author | Chan, HK | en_US |
dc.date.accessioned | 2012-10-30T06:14:04Z | - |
dc.date.available | 2012-10-30T06:14:04Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Pharmaceutical Research, 2011, v. 28 n. 4, p. 788-796 | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171420 | - |
dc.description.abstract | Purpose: To produce and examine the aerosol performance of protein nano-matrix particles with different surface roughness. Methods: Aqueous lysozyme solutions were poured into isopropanol during high-shear mixing to produce nanoparticles by precipitation. The size of the nanoparticles was varied by adjusting the precipitation conditions. The resultant suspensions were spray-dried to obtain micron-sized aggregates (nano-matrices). Smooth particles were made by spray-drying a lysozyme solution. The aggregate size distribution, surface roughness, and cohesion were evaluated. The aerosol performance was assessed by dispersing 10 mg of powder from a Rotahaler ® at 60 L/min or an Aerolizer® at 100 L/min into a Next Generation Impactor, followed by chemical assay (n∈=∈3). Results: The median volume diameter and span of the nano-matrix particles were 1.0-1.2 μm and 1.5-1.6, respectively, which were comparable to those of the smooth particles. Surface roughness increased with the size of the primary nanoparticles. The nano-matrix particles were significantly less cohesive than the smooth particles. The fine particle fraction increased linearly with increasing surface roughness and decreasing cohesion. Conclusions: Nano-matrix particles with controlled surface architecture were successfully produced by spray-drying nanosuspensions. Aerosol performance was enhanced with increasing surface roughness due to the reduction in cohesion forces. © 2010 Springer Science+Business Media, LLC. | en_US |
dc.language | eng | en_US |
dc.publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741 | en_US |
dc.relation.ispartof | Pharmaceutical Research | en_US |
dc.subject | aggregates | - |
dc.subject | dispersion | - |
dc.subject | lysozyme | - |
dc.subject | nano-matrix | - |
dc.subject | roughness | - |
dc.subject.mesh | 2-Propanol - Chemistry | en_US |
dc.subject.mesh | Administration, Inhalation | en_US |
dc.subject.mesh | Aerosols | en_US |
dc.subject.mesh | Chemistry, Pharmaceutical | en_US |
dc.subject.mesh | Drug Carriers - Chemistry | en_US |
dc.subject.mesh | Dry Powder Inhalers | en_US |
dc.subject.mesh | Light | en_US |
dc.subject.mesh | Microscopy, Atomic Force | en_US |
dc.subject.mesh | Microscopy, Electron, Scanning | en_US |
dc.subject.mesh | Muramidase - Chemistry | en_US |
dc.subject.mesh | Nanoparticles - Chemistry | en_US |
dc.subject.mesh | Particle Size | en_US |
dc.subject.mesh | Pharmaceutical Preparations - Administration & Dosage | en_US |
dc.subject.mesh | Scattering, Radiation | en_US |
dc.subject.mesh | Surface Properties | en_US |
dc.title | Formation of protein nano-matrix particles with controlled surface architecture for respiratory drug delivery | en_US |
dc.type | Article | en_US |
dc.identifier.email | Kwok, PCL:pclkwok@hku.hk | en_US |
dc.identifier.authority | Kwok, PCL=rp01540 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s11095-010-0332-2 | en_US |
dc.identifier.pmid | 21136142 | - |
dc.identifier.scopus | eid_2-s2.0-79955603054 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79955603054&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 788 | en_US |
dc.identifier.epage | 796 | en_US |
dc.identifier.eissn | 1573-904X | - |
dc.identifier.isi | WOS:000288805300011 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Kwok, PCL=12646007800 | en_US |
dc.identifier.scopusauthorid | Tunsirikongkon, A=36651806000 | en_US |
dc.identifier.scopusauthorid | Glover, W=7005874010 | en_US |
dc.identifier.scopusauthorid | Chan, HK=7403402677 | en_US |
dc.identifier.citeulike | 8421169 | - |
dc.identifier.issnl | 0724-8741 | - |