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- Publisher Website: 10.1002/(SICI)1097-0223(199905)19:5<463::AID-PD574>3.0.CO;2-Q
- Scopus: eid_2-s2.0-0032927899
- PMID: 10360516
- WOS: WOS:000080433900011
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Article: Second-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian women
Title | Second-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian women |
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Authors | |
Keywords | Asian Down syndrome Inhibin-A Screening |
Issue Date | 1999 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 |
Citation | Prenatal Diagnosis, 1999, v. 19 n. 5, p. 463-467 How to Cite? |
Abstract | Case-control studies in the Caucasian population showed that maternal serum inhibin-A is elevated in Down syndrome pregnancies and may be a useful second-trimester marker in addition to human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP). Data in the Asian population are lacking. We measured inhibin-A levels in the stored maternal sera of 49 Down syndrome pregnancies and 341 controls with a commercially available assay and expressed them as the multiples of the median of the gestational week. The log means and standard deviations for case and control inhibin-A MOMs were 0.209, 0.226, and 0.002 and 0.177, respectively. Median inhibin-A MOM in Down syndrome cases was elevated to 1.62 (95 per cent confidence interval, 1.29-1.82). 36 per cent of Down syndrome cases were expected to be detected at a 5 per cent false-positive rate. However, inhibin-A MOMs were strongly correlated with hCG MOMs in the cases (r = 0.73, p < 0.001) and the controls (r = 0.56, p < 0.001). This will diminish the value of adding inhibin-A to the existing hCG and AFP screening protocol. |
Persistent Identifier | http://hdl.handle.net/10722/180644 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.986 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lam, YH | en_US |
dc.contributor.author | Tang, MHY | en_US |
dc.date.accessioned | 2013-01-28T01:40:51Z | - |
dc.date.available | 2013-01-28T01:40:51Z | - |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | Prenatal Diagnosis, 1999, v. 19 n. 5, p. 463-467 | en_US |
dc.identifier.issn | 0197-3851 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/180644 | - |
dc.description.abstract | Case-control studies in the Caucasian population showed that maternal serum inhibin-A is elevated in Down syndrome pregnancies and may be a useful second-trimester marker in addition to human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP). Data in the Asian population are lacking. We measured inhibin-A levels in the stored maternal sera of 49 Down syndrome pregnancies and 341 controls with a commercially available assay and expressed them as the multiples of the median of the gestational week. The log means and standard deviations for case and control inhibin-A MOMs were 0.209, 0.226, and 0.002 and 0.177, respectively. Median inhibin-A MOM in Down syndrome cases was elevated to 1.62 (95 per cent confidence interval, 1.29-1.82). 36 per cent of Down syndrome cases were expected to be detected at a 5 per cent false-positive rate. However, inhibin-A MOMs were strongly correlated with hCG MOMs in the cases (r = 0.73, p < 0.001) and the controls (r = 0.56, p < 0.001). This will diminish the value of adding inhibin-A to the existing hCG and AFP screening protocol. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 | en_US |
dc.relation.ispartof | Prenatal Diagnosis | en_US |
dc.subject | Asian | - |
dc.subject | Down syndrome | - |
dc.subject | Inhibin-A | - |
dc.subject | Screening | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Asian Continental Ancestry Group | en_US |
dc.subject.mesh | Biological Markers - Blood | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Chorionic Gonadotropin - Blood | en_US |
dc.subject.mesh | Down Syndrome - Blood - Diagnosis - Embryology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fetal Diseases - Blood - Diagnosis | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Inhibins - Blood | en_US |
dc.subject.mesh | Predictive Value Of Tests | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy Trimester, Second | en_US |
dc.subject.mesh | Prenatal Diagnosis | en_US |
dc.subject.mesh | Alpha-Fetoproteins - Analysis | en_US |
dc.title | Second-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian women | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, MHY=rp01701 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/(SICI)1097-0223(199905)19:5<463::AID-PD574>3.0.CO;2-Q | en_US |
dc.identifier.pmid | 10360516 | - |
dc.identifier.scopus | eid_2-s2.0-0032927899 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032927899&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 19 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 463 | en_US |
dc.identifier.epage | 467 | en_US |
dc.identifier.isi | WOS:000080433900011 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Lam, YH=7202563903 | en_US |
dc.identifier.scopusauthorid | Tang, MHY=8943401300 | en_US |
dc.identifier.issnl | 0197-3851 | - |