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Conference Paper: Targeting AMPK as a valid therapeutic intervention in ovarian cancer
Title | Targeting AMPK as a valid therapeutic intervention in ovarian cancer |
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Authors | |
Issue Date | 2014 |
Citation | The 2014 International Workshop on Women's Reproductive Health Research, Ottawa, Canada, 11-13 April 2014. How to Cite? |
Abstract | Despite advances in diagnosis and treatment, the incidence of ovarian cancer is rising and the associated mortality rate has not improved significantly over the past decade. Therefore, discovery of novel targets for therapies will improve the quality of life of patients. AMP-activated protein kinase (AMPK) is an energy-sensor that maintains energy homeostasis in eukaryotic cells. Accumulating evidence has shown that AMPK activation suppresses cell proliferation in response to metabolic stress and induces apoptosis in many human cancer cells. AMPK is a heterotrimer composed of a catalytic subunit (α) and two regulatory subunits (β and γ). Our previous studies found that AMPK subunits are aberrantly expressed in ovarian cancer, and their expressions have significant correlations with ovarian cancer progression (Li et al, 2012). Indeed, we have recently reported that the reduced expression of AMPK-β1 confers lower AMPK activity, which enhances the oncogenic capacity of advanced-stage ovarian cancer (Li, C. et al, 2014, in press). |
Persistent Identifier | http://hdl.handle.net/10722/197740 |
DC Field | Value | Language |
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dc.contributor.author | Chan, DW | en_US |
dc.contributor.author | Ngan, HYS | en_US |
dc.date.accessioned | 2014-05-29T08:46:47Z | - |
dc.date.available | 2014-05-29T08:46:47Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | The 2014 International Workshop on Women's Reproductive Health Research, Ottawa, Canada, 11-13 April 2014. | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/197740 | - |
dc.description.abstract | Despite advances in diagnosis and treatment, the incidence of ovarian cancer is rising and the associated mortality rate has not improved significantly over the past decade. Therefore, discovery of novel targets for therapies will improve the quality of life of patients. AMP-activated protein kinase (AMPK) is an energy-sensor that maintains energy homeostasis in eukaryotic cells. Accumulating evidence has shown that AMPK activation suppresses cell proliferation in response to metabolic stress and induces apoptosis in many human cancer cells. AMPK is a heterotrimer composed of a catalytic subunit (α) and two regulatory subunits (β and γ). Our previous studies found that AMPK subunits are aberrantly expressed in ovarian cancer, and their expressions have significant correlations with ovarian cancer progression (Li et al, 2012). Indeed, we have recently reported that the reduced expression of AMPK-β1 confers lower AMPK activity, which enhances the oncogenic capacity of advanced-stage ovarian cancer (Li, C. et al, 2014, in press). | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | International Workshop on Women's Reproductive Health Research | en_US |
dc.title | Targeting AMPK as a valid therapeutic intervention in ovarian cancer | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Chan, DW: dwchan@hku.hk | en_US |
dc.identifier.email | Ngan, HYS: hysngan@hkucc.hku.hk | en_US |
dc.identifier.authority | Chan, DW=rp00543 | en_US |
dc.identifier.authority | Ngan, HYS=rp00346 | en_US |
dc.identifier.hkuros | 228889 | en_US |