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Conference Paper: Predictors of relapse in early psychosis: a 3-year retrospective chort study in Hong Kong
Title | Predictors of relapse in early psychosis: a 3-year retrospective chort study in Hong Kong |
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Authors | |
Issue Date | 2014 |
Publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://easap.asia/index.htm |
Citation | The 2014 Regional Congress of the World Psychiatric Association (WPA), Hong Kong, 12-14 December 2014., v. 24 n. 4 suppl., p. 20-21, abstract RS2.2.3 How to Cite? |
Abstract | OBJECTIVE: Relapse prevention is one of the most important and challenging targets in the treatment of psychotic disorders. However, apart from medication discontinuation, consistent relapse predictor has not been identified. We aimed to investigate relapse predictors in a large cohort of patients with first-episode psychosis. METHOD: This was a retrospective cohort study designed to evaluate relapses in first-episode psychosis patients in 3 years. A total of 1,400 patients’ case records were retrieved from a hospital database. Potential relapse predictors including demographic variables, baseline clinical measures, medication adherence, and residual positive symptoms upon clinical stabilisation were collected. RESULTS: The cumulative relapse rates were 19.3% by year 1, 38.4% by year 2, and 48.1% by year 3. Multivariate Cox-proportional hazards regression analysis revealed that medication non-adherence, smoking, schizophrenia diagnosis, younger age, and shorter baseline hospitalization were associated with an increased risk of relapse in 3 years. CONCLUSIONS: Nearly half of the patients relapsed after 3 years following their first-episode psychosis. Smoking as a predictor of relapse is an intriguing new finding supportive of a link between nicotinic receptors and the dopamine system. Their relationship deserves further investigations with potential clinical implications for relapse prevention in psychosis. |
Description | Congress Theme: Yin and Yang of Mental Health in Asia - Balancing Polaritie Regular Symposium 2.2 – Early Psychosis: no. RS2.2.3 |
Persistent Identifier | http://hdl.handle.net/10722/214247 |
ISSN | 2023 SCImago Journal Rankings: 0.364 |
DC Field | Value | Language |
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dc.contributor.author | Hui, CLM | - |
dc.contributor.author | Tang, JYM | - |
dc.contributor.author | Chang, WC | - |
dc.contributor.author | Chan, SKW | - |
dc.contributor.author | Lee, EHM | - |
dc.contributor.author | Chen, EYH | - |
dc.date.accessioned | 2015-08-21T11:01:39Z | - |
dc.date.available | 2015-08-21T11:01:39Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | The 2014 Regional Congress of the World Psychiatric Association (WPA), Hong Kong, 12-14 December 2014., v. 24 n. 4 suppl., p. 20-21, abstract RS2.2.3 | - |
dc.identifier.issn | 2078-9947 | - |
dc.identifier.uri | http://hdl.handle.net/10722/214247 | - |
dc.description | Congress Theme: Yin and Yang of Mental Health in Asia - Balancing Polaritie | - |
dc.description | Regular Symposium 2.2 – Early Psychosis: no. RS2.2.3 | - |
dc.description.abstract | OBJECTIVE: Relapse prevention is one of the most important and challenging targets in the treatment of psychotic disorders. However, apart from medication discontinuation, consistent relapse predictor has not been identified. We aimed to investigate relapse predictors in a large cohort of patients with first-episode psychosis. METHOD: This was a retrospective cohort study designed to evaluate relapses in first-episode psychosis patients in 3 years. A total of 1,400 patients’ case records were retrieved from a hospital database. Potential relapse predictors including demographic variables, baseline clinical measures, medication adherence, and residual positive symptoms upon clinical stabilisation were collected. RESULTS: The cumulative relapse rates were 19.3% by year 1, 38.4% by year 2, and 48.1% by year 3. Multivariate Cox-proportional hazards regression analysis revealed that medication non-adherence, smoking, schizophrenia diagnosis, younger age, and shorter baseline hospitalization were associated with an increased risk of relapse in 3 years. CONCLUSIONS: Nearly half of the patients relapsed after 3 years following their first-episode psychosis. Smoking as a predictor of relapse is an intriguing new finding supportive of a link between nicotinic receptors and the dopamine system. Their relationship deserves further investigations with potential clinical implications for relapse prevention in psychosis. | - |
dc.language | eng | - |
dc.publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://easap.asia/index.htm | - |
dc.relation.ispartof | East Asian Archives of Psychiatry | - |
dc.relation.ispartof | 東亞精神科學志 | - |
dc.rights | East Asian Archives of Psychiatry. Copyright © Hong Kong Academy of Medicine Press. | - |
dc.title | Predictors of relapse in early psychosis: a 3-year retrospective chort study in Hong Kong | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Hui, CLM: christyh@hkucc.hku.hk | - |
dc.identifier.email | Tang, JYM: jennitym@hkucc.hku.hk | - |
dc.identifier.email | Chang, WC: changwc@hku.hk | - |
dc.identifier.email | Chan, SKW: kwsherry@hku.hk | - |
dc.identifier.email | Lee, EHM: edwinlhm@hku.hk | - |
dc.identifier.email | Chen, EYH: eyhchen@hku.hk | - |
dc.identifier.authority | Hui, CLM=rp01993 | - |
dc.identifier.authority | Tang, JYM=rp01997 | - |
dc.identifier.authority | Chang, WC=rp01465 | - |
dc.identifier.authority | Chan, SKW=rp00539 | - |
dc.identifier.authority | Lee, EHM=rp01575 | - |
dc.identifier.authority | Chen, EYH=rp00392 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 249108 | - |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 4 suppl. | - |
dc.identifier.spage | 20, abstract RS2.2.3 | - |
dc.identifier.epage | 21 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 2078-9947 | - |