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Conference Paper: Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models
Title | Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models |
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Authors | |
Issue Date | 2017 |
Publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/ |
Citation | The 22nd Medical Research Conference (MRC 2017), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 14 January 2017. In Hong Kong Medical Journal, 2017, v. 23 n. 1 suppl. 1, p. 26, abstrcat no. 33 How to Cite? |
Abstract | INTRODUCTION: Arginine depletion has shown anticancer effects among arginine auxotrophic cancers. Pegylated arginase (BCT-100) depletes arginine by converting arginine to ornithine. In this study, BCT-100 inhibited cell growth in a panel of lung adenocarcinoma cell lines while stimulated tumor growth in most lung adenocarcinoma xenograft models. Furthermore, ornithine decarboxylase (ODC) was induced by BCT-100 in two solid xenograft models with tumor growth stimulating effect. We postulate that accumulated ornithine was used to produce polyamines by ODC which promoted tumor growth. And ODC inhibition might rescue the therapeutic effect of BCT-100 treatment in lung adenocarcinoma ... |
Persistent Identifier | http://hdl.handle.net/10722/240126 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.261 |
DC Field | Value | Language |
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dc.contributor.author | Lam, SK | - |
dc.contributor.author | Xu, S | - |
dc.contributor.author | Ho, JCM | - |
dc.date.accessioned | 2017-04-13T00:59:37Z | - |
dc.date.available | 2017-04-13T00:59:37Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | The 22nd Medical Research Conference (MRC 2017), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 14 January 2017. In Hong Kong Medical Journal, 2017, v. 23 n. 1 suppl. 1, p. 26, abstrcat no. 33 | - |
dc.identifier.issn | 1024-2708 | - |
dc.identifier.uri | http://hdl.handle.net/10722/240126 | - |
dc.description.abstract | INTRODUCTION: Arginine depletion has shown anticancer effects among arginine auxotrophic cancers. Pegylated arginase (BCT-100) depletes arginine by converting arginine to ornithine. In this study, BCT-100 inhibited cell growth in a panel of lung adenocarcinoma cell lines while stimulated tumor growth in most lung adenocarcinoma xenograft models. Furthermore, ornithine decarboxylase (ODC) was induced by BCT-100 in two solid xenograft models with tumor growth stimulating effect. We postulate that accumulated ornithine was used to produce polyamines by ODC which promoted tumor growth. And ODC inhibition might rescue the therapeutic effect of BCT-100 treatment in lung adenocarcinoma ... | - |
dc.language | eng | - |
dc.publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/ | - |
dc.relation.ispartof | Hong Kong Medical Journal | - |
dc.rights | Hong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Lam, SK: sklam77@hku.hk | - |
dc.identifier.email | Ho, JCM: jhocm@hku.hk | - |
dc.identifier.authority | Ho, JCM=rp00258 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.hkuros | 271713 | - |
dc.identifier.volume | 23 | - |
dc.identifier.issue | 1 suppl. 1 | - |
dc.identifier.spage | 26, abstrcat no. 33 | - |
dc.identifier.epage | 26, abstrcat no. 33 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 1024-2708 | - |