File Download
There are no files associated with this item.
Supplementary
-
Citations:
- Appears in Collections:
Conference Paper: Self-assembled synthetic ion channels
Title | Self-assembled synthetic ion channels |
---|---|
Authors | |
Issue Date | 2017 |
Publisher | American Chemical Society. |
Citation | The 253rd American Chemical Society National Meeting & Exposition
, San Francisco, CA, 2–6 April 2017 How to Cite? |
Abstract | Unlike ion channel modulators that act on natural ion channel proteins, synthetic ion channels are small organic molecules that self-assemble to form ion channels in cell membranes irrespective of the presence of natural ion channels. By using HPTS assay, Ussing chamber, and patch-clamp single channel recording, we have discovered a range of small molecules with unique physical properties and excellent ion selectivity. In addition, on the basis of structural studied using STD-NMR, NOESY-NMR and CD methods, we have proposed models of self-assembled ion channels and further evaluated them using all-atom molecular dynamics simulations. Those synthetic ion channels may offer great opportunity to resolve unmet medical needs. |
Description | Session: Current Topics in Biochemistry - no. BIOL 202 |
Persistent Identifier | http://hdl.handle.net/10722/247751 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, D | - |
dc.date.accessioned | 2017-10-18T08:32:04Z | - |
dc.date.available | 2017-10-18T08:32:04Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | The 253rd American Chemical Society National Meeting & Exposition , San Francisco, CA, 2–6 April 2017 | - |
dc.identifier.uri | http://hdl.handle.net/10722/247751 | - |
dc.description | Session: Current Topics in Biochemistry - no. BIOL 202 | - |
dc.description.abstract | Unlike ion channel modulators that act on natural ion channel proteins, synthetic ion channels are small organic molecules that self-assemble to form ion channels in cell membranes irrespective of the presence of natural ion channels. By using HPTS assay, Ussing chamber, and patch-clamp single channel recording, we have discovered a range of small molecules with unique physical properties and excellent ion selectivity. In addition, on the basis of structural studied using STD-NMR, NOESY-NMR and CD methods, we have proposed models of self-assembled ion channels and further evaluated them using all-atom molecular dynamics simulations. Those synthetic ion channels may offer great opportunity to resolve unmet medical needs. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. | - |
dc.relation.ispartof | American Chemical Society National Meeting & Exposition, April 2017 | - |
dc.title | Self-assembled synthetic ion channels | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Yang, D: yangdan@hku.hk | - |
dc.identifier.authority | Yang, D=rp00825 | - |
dc.identifier.hkuros | 281536 | - |
dc.publisher.place | San Francisco, CA | - |