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- Publisher Website: 10.1159/000149852
- Scopus: eid_2-s2.0-0016347237
- PMID: 4376544
- WOS: WOS:A1974AB03100001
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Article: Inactivation of Mouse Elberfeld virus by periodate
Title | Inactivation of Mouse Elberfeld virus by periodate |
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Authors | |
Issue Date | 1974 |
Citation | Intervirology, 1974, v. 4, n. 3, p. 129-139 How to Cite? |
Abstract | Mouse Elberfeld virus (ME virus) is rapidly inactivated by sodium metaperiodate at millimolar concentrations. Inactivation was observed at all pH's examined from 3 to 8, but showed 2 distinct optima, one at pH 4 and another at pH 7. Inactivation was accompanied at both pH's by complete dissociation of the virion into its protein and RNA components. The infectivity of the RNA recovered from inactivated virions was the same as that of the untreated control. It is concluded that inactivation of viral infectivity is not due to attack on the RNA genome but rather to attack by periodate on some components of the viral capsid. The possible identity of the periodate sensitive site is discussed. |
Persistent Identifier | http://hdl.handle.net/10722/291359 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 0.556 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Mak, T. W. | - |
dc.contributor.author | Rueckert, R. R. | - |
dc.date.accessioned | 2020-11-17T14:54:12Z | - |
dc.date.available | 2020-11-17T14:54:12Z | - |
dc.date.issued | 1974 | - |
dc.identifier.citation | Intervirology, 1974, v. 4, n. 3, p. 129-139 | - |
dc.identifier.issn | 0300-5526 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291359 | - |
dc.description.abstract | Mouse Elberfeld virus (ME virus) is rapidly inactivated by sodium metaperiodate at millimolar concentrations. Inactivation was observed at all pH's examined from 3 to 8, but showed 2 distinct optima, one at pH 4 and another at pH 7. Inactivation was accompanied at both pH's by complete dissociation of the virion into its protein and RNA components. The infectivity of the RNA recovered from inactivated virions was the same as that of the untreated control. It is concluded that inactivation of viral infectivity is not due to attack on the RNA genome but rather to attack by periodate on some components of the viral capsid. The possible identity of the periodate sensitive site is discussed. | - |
dc.language | eng | - |
dc.relation.ispartof | Intervirology | - |
dc.title | Inactivation of Mouse Elberfeld virus by periodate | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1159/000149852 | - |
dc.identifier.pmid | 4376544 | - |
dc.identifier.scopus | eid_2-s2.0-0016347237 | - |
dc.identifier.volume | 4 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 129 | - |
dc.identifier.epage | 139 | - |
dc.identifier.isi | WOS:A1974AB03100001 | - |
dc.identifier.issnl | 0300-5526 | - |