File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Structural and functional changes in the brain of patients with Crohn’s disease: an activation likelihood estimation meta-analysis

TitleStructural and functional changes in the brain of patients with Crohn’s disease: an activation likelihood estimation meta-analysis
Authors
KeywordsCrohn’s disease
Crohn’s disease
Magnetic resonance imaging
Neuroscience
Neuroimaging
Issue Date2021
PublisherSpringer New York LLC.
Citation
Brain Imaging and Behavior, 2021, v. 15, p. 807-818 How to Cite?
AbstractMultiple reports for brain functional and structural alterations in patients with Crohn’s disease (CD) were published. The current study aimed to meta-analyze the existing neuroimaging data and hence produce a brain map revealing areas with functional and structural differences between patients with CD and healthy controls. Original studies published until 2019 were identified from Scopus, Web of Science and PubMed databases, and included into the analysis if they reported relevant results from task-related or resting state functional magnetic resonance imaging (fMRI or rsfMRI) or voxel-based morphometry (VBM), in the form of standardized brain coordinates based on whole-brain analysis. The brain coordinates and sample size of significant results were extracted from eligible studies to be meta-analyzed with the activation likelihood estimation method using the GingerALE software. Sixteen original studies comprised of a total of 865 participants fulfilled the inclusion criteria. Compared to healthy controls, patients with CD had reduced resting state brain connectivity in the paracentral lobule and cingulate gyrus as well as reduced grey matter volume in the medial frontal gyrus. No significant results were found vice versa. These neural correlates allow a better understanding on the effects of CD on the pain expectation, emotion, and quality of life of patients and potentially serve as useful biomarkers for evaluating treatment efficacy.
Persistent Identifierhttp://hdl.handle.net/10722/299140
ISSN
2019 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.980

 

DC FieldValueLanguage
dc.contributor.authorYeung, AWK-
dc.date.accessioned2021-04-28T02:26:43Z-
dc.date.available2021-04-28T02:26:43Z-
dc.date.issued2021-
dc.identifier.citationBrain Imaging and Behavior, 2021, v. 15, p. 807-818-
dc.identifier.issn1931-7557-
dc.identifier.urihttp://hdl.handle.net/10722/299140-
dc.description.abstractMultiple reports for brain functional and structural alterations in patients with Crohn’s disease (CD) were published. The current study aimed to meta-analyze the existing neuroimaging data and hence produce a brain map revealing areas with functional and structural differences between patients with CD and healthy controls. Original studies published until 2019 were identified from Scopus, Web of Science and PubMed databases, and included into the analysis if they reported relevant results from task-related or resting state functional magnetic resonance imaging (fMRI or rsfMRI) or voxel-based morphometry (VBM), in the form of standardized brain coordinates based on whole-brain analysis. The brain coordinates and sample size of significant results were extracted from eligible studies to be meta-analyzed with the activation likelihood estimation method using the GingerALE software. Sixteen original studies comprised of a total of 865 participants fulfilled the inclusion criteria. Compared to healthy controls, patients with CD had reduced resting state brain connectivity in the paracentral lobule and cingulate gyrus as well as reduced grey matter volume in the medial frontal gyrus. No significant results were found vice versa. These neural correlates allow a better understanding on the effects of CD on the pain expectation, emotion, and quality of life of patients and potentially serve as useful biomarkers for evaluating treatment efficacy.-
dc.languageeng-
dc.publisherSpringer New York LLC.-
dc.relation.ispartofBrain Imaging and Behavior-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectCrohn’s disease-
dc.subjectCrohn’s disease-
dc.subjectMagnetic resonance imaging-
dc.subjectNeuroscience-
dc.subjectNeuroimaging-
dc.titleStructural and functional changes in the brain of patients with Crohn’s disease: an activation likelihood estimation meta-analysis-
dc.typeArticle-
dc.identifier.emailYeung, AWK: ndyeung@hku.hk-
dc.identifier.authorityYeung, AWK=rp02143-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11682-020-00291-w-
dc.identifier.pmid32333318-
dc.identifier.scopuseid_2-s2.0-85084125189-
dc.identifier.hkuros322182-
dc.identifier.volume15-
dc.identifier.spage807-
dc.identifier.epage818-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats