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Article: The toxicology and detoxification of Aconitum: traditional and modern views

TitleThe toxicology and detoxification of Aconitum: traditional and modern views
Authors
KeywordsAconitum
Aconitine
Toxicology
Drug processing
Detoxification
Issue Date2021
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/home
Citation
Chinese Medicine, 2021, v. 16 n. 1, p. article no. 61 How to Cite?
AbstractAconitum carmichaeli Debx.-derived herbal medicine has been used for anti-inflammation and anti-arrhythmia purpose for more than two thousand years. It is processed into Chuanwu (Radix Aconiti praeparata) and Fuzi (Radix Aconiti lateralis praeparata) in Traditional Chinese Medicine, which are two useful drugs but with toxic properties. There have been patients poisoned by accidental ingestion of Aconitum plants or misuse of the herbal drug, and this is of great concern to study in-depth. In this review, we provided the traditional and contemporary practice of using Aconitum herbs as medicine, from functions, processing methods to toxicity in ethnomedicine aspects to discuss the underlying connections of traditional and modern understanding on the toxicity of Aconitum plants. We summarized the functions and toxicology of the herbal drugs are analyzed from chemical and clinical aspects, with the help of traditional and modern knowledge of medicine. The medicinal doses and lethal doses determined by researches are summarized, and the usage and processing methods are updated and reviewed in the modern view. In addition, clinical management of poisoned cases using western medicine is discussed. This review provides insights and awareness of safety when using Aconitum-derived herbal medicine, and the application of modern scientific knowledge to optimize the detoxification processes. We suggest the possibility to renew the current standard processing method from the official Pharmacopoeia all over the world.
Persistent Identifierhttp://hdl.handle.net/10722/301534
ISSN
2020 Impact Factor: 5.455
2020 SCImago Journal Rankings: 0.972
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorCHAN, YT-
dc.contributor.authorWang, N-
dc.contributor.authorFeng, Y-
dc.date.accessioned2021-08-09T03:40:28Z-
dc.date.available2021-08-09T03:40:28Z-
dc.date.issued2021-
dc.identifier.citationChinese Medicine, 2021, v. 16 n. 1, p. article no. 61-
dc.identifier.issn1749-8546-
dc.identifier.urihttp://hdl.handle.net/10722/301534-
dc.description.abstractAconitum carmichaeli Debx.-derived herbal medicine has been used for anti-inflammation and anti-arrhythmia purpose for more than two thousand years. It is processed into Chuanwu (Radix Aconiti praeparata) and Fuzi (Radix Aconiti lateralis praeparata) in Traditional Chinese Medicine, which are two useful drugs but with toxic properties. There have been patients poisoned by accidental ingestion of Aconitum plants or misuse of the herbal drug, and this is of great concern to study in-depth. In this review, we provided the traditional and contemporary practice of using Aconitum herbs as medicine, from functions, processing methods to toxicity in ethnomedicine aspects to discuss the underlying connections of traditional and modern understanding on the toxicity of Aconitum plants. We summarized the functions and toxicology of the herbal drugs are analyzed from chemical and clinical aspects, with the help of traditional and modern knowledge of medicine. The medicinal doses and lethal doses determined by researches are summarized, and the usage and processing methods are updated and reviewed in the modern view. In addition, clinical management of poisoned cases using western medicine is discussed. This review provides insights and awareness of safety when using Aconitum-derived herbal medicine, and the application of modern scientific knowledge to optimize the detoxification processes. We suggest the possibility to renew the current standard processing method from the official Pharmacopoeia all over the world.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/home-
dc.relation.ispartofChinese Medicine-
dc.rightsChinese Medicine. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAconitum-
dc.subjectAconitine-
dc.subjectToxicology-
dc.subjectDrug processing-
dc.subjectDetoxification-
dc.titleThe toxicology and detoxification of Aconitum: traditional and modern views-
dc.typeArticle-
dc.identifier.emailWang, N: ckwang@hku.hk-
dc.identifier.emailFeng, Y: yfeng@hku.hk-
dc.identifier.authorityWang, N=rp02075-
dc.identifier.authorityFeng, Y=rp00466-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s13020-021-00472-9-
dc.identifier.pmid34315520-
dc.identifier.pmcidPMC8314510-
dc.identifier.scopuseid_2-s2.0-85111380192-
dc.identifier.hkuros324023-
dc.identifier.volume16-
dc.identifier.issue1-
dc.identifier.spagearticle no. 61-
dc.identifier.epagearticle no. 61-
dc.publisher.placeUnited Kingdom-

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