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Article: The effect of birth weight on body composition: Evidence from a birth cohort and a Mendelian randomization study
Title | The effect of birth weight on body composition: Evidence from a birth cohort and a Mendelian randomization study |
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Authors | |
Issue Date | 2019 |
Publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action |
Citation | PLoS One, 2019, v. 14 n. 9, p. article no. e0222141 How to Cite? |
Abstract | Background: Lower birth weight is associated with diabetes although the underlying mechanisms are unclear. Muscle mass could be a modifiable link and hence a target of intervention. We assessed the associations of birth weight with muscle and fat mass observationally in a population with little socio-economic patterning of birth weight and using Mendelian randomization (MR) for validation.
Methods: In the population-representative 'Children of 1997' birth cohort (n = 8,327), we used multivariable linear regression to assess the adjusted associations of birth weight (kg) with muscle mass (kg) and body fat (%) at ~17.5 years. Genetically predicted birth weight (effect size) was applied to summary genetic associations with fat-free mass and fat mass (kg) from the UK Biobank (n = ~331,000) to obtain unconfounded estimates using inverse-variance weighting.
Results: Observationally, birth weight was positively associated with muscle mass (3.29 kg per kg birth weight, 95% confidence interval (CI) 2.83 to 3.75) and body fat (1.09% per kg birth weight, 95% CI 0.54 to 1.65). Stronger associations with muscle mass were observed in boys than in girls (p for interaction 0.004). Using MR, birth weight was positively associated with fat-free mass (0.77 kg per birth weight z-score, 95% CI 0.22 to 1.33) and fat mass (0.58, 95% CI 0.01 to 1.15). No difference by sex was evident.
Conclusion: Higher birth weight increasing muscle mass may be relevant to lower birth weight increasing the risk of diabetes and suggests post-natal muscle mass as a potential target of intervention. |
Persistent Identifier | http://hdl.handle.net/10722/305236 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.839 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LIU, J | - |
dc.contributor.author | Au Yeung, SL | - |
dc.contributor.author | HE, B | - |
dc.contributor.author | Kwok, MK | - |
dc.contributor.author | Leung, GM | - |
dc.contributor.author | Schooling, CM | - |
dc.date.accessioned | 2021-10-20T10:06:34Z | - |
dc.date.available | 2021-10-20T10:06:34Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | PLoS One, 2019, v. 14 n. 9, p. article no. e0222141 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/10722/305236 | - |
dc.description.abstract | Background: Lower birth weight is associated with diabetes although the underlying mechanisms are unclear. Muscle mass could be a modifiable link and hence a target of intervention. We assessed the associations of birth weight with muscle and fat mass observationally in a population with little socio-economic patterning of birth weight and using Mendelian randomization (MR) for validation. Methods: In the population-representative 'Children of 1997' birth cohort (n = 8,327), we used multivariable linear regression to assess the adjusted associations of birth weight (kg) with muscle mass (kg) and body fat (%) at ~17.5 years. Genetically predicted birth weight (effect size) was applied to summary genetic associations with fat-free mass and fat mass (kg) from the UK Biobank (n = ~331,000) to obtain unconfounded estimates using inverse-variance weighting. Results: Observationally, birth weight was positively associated with muscle mass (3.29 kg per kg birth weight, 95% confidence interval (CI) 2.83 to 3.75) and body fat (1.09% per kg birth weight, 95% CI 0.54 to 1.65). Stronger associations with muscle mass were observed in boys than in girls (p for interaction 0.004). Using MR, birth weight was positively associated with fat-free mass (0.77 kg per birth weight z-score, 95% CI 0.22 to 1.33) and fat mass (0.58, 95% CI 0.01 to 1.15). No difference by sex was evident. Conclusion: Higher birth weight increasing muscle mass may be relevant to lower birth weight increasing the risk of diabetes and suggests post-natal muscle mass as a potential target of intervention. | - |
dc.language | eng | - |
dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | - |
dc.relation.ispartof | PLoS One | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | The effect of birth weight on body composition: Evidence from a birth cohort and a Mendelian randomization study | - |
dc.type | Article | - |
dc.identifier.email | Au Yeung, SL: ayslryan@hku.hk | - |
dc.identifier.email | Kwok, MK: maggiek@hku.hk | - |
dc.identifier.email | Leung, GM: gmleung@hku.hk | - |
dc.identifier.email | Schooling, CM: cms1@hkucc.hku.hk | - |
dc.identifier.authority | Au Yeung, SL=rp02224 | - |
dc.identifier.authority | Kwok, MK=rp02051 | - |
dc.identifier.authority | Leung, GM=rp00460 | - |
dc.identifier.authority | Schooling, CM=rp00504 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1371/journal.pone.0222141 | - |
dc.identifier.pmid | 31504067 | - |
dc.identifier.pmcid | PMC6736493 | - |
dc.identifier.scopus | eid_2-s2.0-85072033906 | - |
dc.identifier.hkuros | 327208 | - |
dc.identifier.hkuros | 325792 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | article no. e0222141 | - |
dc.identifier.epage | article no. e0222141 | - |
dc.identifier.isi | WOS:000532172700022 | - |
dc.publisher.place | United States | - |