File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.tig.2024.02.005
- Scopus: eid_2-s2.0-85188008325
- Find via
Supplementary
-
Citations:
- Scopus: 0
- Appears in Collections:
Article: Single-cell phylotranscriptomics of developmental and cell type evolution
Title | Single-cell phylotranscriptomics of developmental and cell type evolution |
---|---|
Authors | |
Keywords | cell type developmental hourglass pattern evolution phylotranscriptomics single-cell transcriptomics |
Issue Date | 14-Mar-2024 |
Publisher | Cell Press |
Citation | Trends in Genetics, 2024, v. 40, n. 6, p. 495-510 How to Cite? |
Abstract | Single-cell phylotranscriptomics is an emerging tool to reveal the molecular and cellular mechanisms of evolution. We summarize its utility in studying the hourglass pattern of ontogenetic evolution and for understanding the evolutionary history of cell types. The developmental hourglass model suggests that the mid-embryonic stage is the most conserved period of development across species, which is supported by morphological and molecular studies. Single-cell phylotranscriptomic analysis has revealed previously underappreciated heterogeneity in transcriptome ages among lineages and cell types throughout development, and has identified the lineages and tissues that drive the whole-organism hourglass pattern. Single-cell transcriptome age analyses also provide important insights into the origin of germ layers, the different selective forces on tissues during adaptation, and the evolutionary relationships between cell types. |
Persistent Identifier | http://hdl.handle.net/10722/344965 |
ISSN | 2023 Impact Factor: 13.6 2023 SCImago Journal Rankings: 3.690 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ma, Fuqiang | - |
dc.contributor.author | Zheng, Chaogu | - |
dc.date.accessioned | 2024-08-14T08:56:33Z | - |
dc.date.available | 2024-08-14T08:56:33Z | - |
dc.date.issued | 2024-03-14 | - |
dc.identifier.citation | Trends in Genetics, 2024, v. 40, n. 6, p. 495-510 | - |
dc.identifier.issn | 0168-9525 | - |
dc.identifier.uri | http://hdl.handle.net/10722/344965 | - |
dc.description.abstract | <p>Single-cell phylotranscriptomics is an emerging tool to reveal the molecular and cellular mechanisms of evolution. We summarize its utility in studying the hourglass pattern of ontogenetic evolution and for understanding the evolutionary history of cell types. The developmental hourglass model suggests that the mid-embryonic stage is the most conserved period of development across species, which is supported by morphological and molecular studies. Single-cell phylotranscriptomic analysis has revealed previously underappreciated heterogeneity in transcriptome ages among lineages and cell types throughout development, and has identified the lineages and tissues that drive the whole-organism hourglass pattern. Single-cell transcriptome age analyses also provide important insights into the origin of germ layers, the different selective forces on tissues during adaptation, and the evolutionary relationships between cell types.<br></p> | - |
dc.language | eng | - |
dc.publisher | Cell Press | - |
dc.relation.ispartof | Trends in Genetics | - |
dc.subject | cell type | - |
dc.subject | developmental hourglass pattern | - |
dc.subject | evolution | - |
dc.subject | phylotranscriptomics | - |
dc.subject | single-cell transcriptomics | - |
dc.title | Single-cell phylotranscriptomics of developmental and cell type evolution | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.tig.2024.02.005 | - |
dc.identifier.scopus | eid_2-s2.0-85188008325 | - |
dc.identifier.volume | 40 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 495 | - |
dc.identifier.epage | 510 | - |
dc.identifier.eissn | 1362-4555 | - |
dc.identifier.issnl | 0168-9525 | - |