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- Publisher Website: 10.1089/ten.2006.12.3181
- Scopus: eid_2-s2.0-33751576552
- PMID: 17518632
- WOS: WOS:000242400200016
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Article: Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model
Title | Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model |
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Authors | |
Issue Date | 2006 |
Publisher | Mary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/ten |
Citation | Tissue Engineering, 2006, v. 12 n. 11, p. 3181-3188 How to Cite? |
Abstract | This study aims to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on mandibular distraction at routine and rapid distraction rates. Eighteen New Zealand white rabbits were assigned to 2 groups, 1 treated at a routine distraction rate (0.9 mm/d) and the other at a rapid distraction rate (2.7 mm/d). rhBMP-2 was injected into 1 side of the distraction regenerate at the end of the active distraction period; the contralateral side was used as a control. The distraction regenerates were analyzed by plain radiography, microcomputed tomography, and histologic examination. The results showed that rhBMP-2 can promote bone formation at both rapid and routine distraction rates, but no statistically significant difference was observed between the bone morphogenetic protein injection sides of the rapid and routine distraction groups. In conclusion, the study indicates that rhBMP-2 can enhance bone ossification at both routine and rapid distraction rates. The addition of rhBMP-2 seems to be able to compensate for the rapid distraction rate in mandibular distraction osteogenesis. Further long-term follow-up and mechanical strength test for the support of implants or conventional prostheses are necessary. © Mary Ann Liebert, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/67109 |
ISSN | 2017 Impact Factor: 3.508 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Li, WZ | en_HK |
dc.contributor.author | Lim, KC | en_HK |
dc.date.accessioned | 2010-09-06T05:52:02Z | - |
dc.date.available | 2010-09-06T05:52:02Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Tissue Engineering, 2006, v. 12 n. 11, p. 3181-3188 | en_HK |
dc.identifier.issn | 2152-4947 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67109 | - |
dc.description.abstract | This study aims to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on mandibular distraction at routine and rapid distraction rates. Eighteen New Zealand white rabbits were assigned to 2 groups, 1 treated at a routine distraction rate (0.9 mm/d) and the other at a rapid distraction rate (2.7 mm/d). rhBMP-2 was injected into 1 side of the distraction regenerate at the end of the active distraction period; the contralateral side was used as a control. The distraction regenerates were analyzed by plain radiography, microcomputed tomography, and histologic examination. The results showed that rhBMP-2 can promote bone formation at both rapid and routine distraction rates, but no statistically significant difference was observed between the bone morphogenetic protein injection sides of the rapid and routine distraction groups. In conclusion, the study indicates that rhBMP-2 can enhance bone ossification at both routine and rapid distraction rates. The addition of rhBMP-2 seems to be able to compensate for the rapid distraction rate in mandibular distraction osteogenesis. Further long-term follow-up and mechanical strength test for the support of implants or conventional prostheses are necessary. © Mary Ann Liebert, Inc. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Mary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/ten | en_HK |
dc.relation.ispartof | Tissue Engineering | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Bone Morphogenetic Protein 2 | en_HK |
dc.subject.mesh | Bone Morphogenetic Proteins - genetics - pharmacology - therapeutic use | en_HK |
dc.subject.mesh | Bone Regeneration - drug effects - physiology | en_HK |
dc.subject.mesh | Bone Remodeling - drug effects - physiology | en_HK |
dc.subject.mesh | Histocytochemistry | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Kinetics | en_HK |
dc.subject.mesh | Mandible - drug effects - metabolism - physiopathology - radiography - surgery | en_HK |
dc.subject.mesh | Models, Animal | en_HK |
dc.subject.mesh | Osteogenesis - drug effects - physiology | en_HK |
dc.subject.mesh | Osteogenesis, Distraction - methods | en_HK |
dc.subject.mesh | Rabbits | en_HK |
dc.subject.mesh | Random Allocation | en_HK |
dc.subject.mesh | Recombinant Proteins - pharmacology | en_HK |
dc.subject.mesh | Tomography, X-Ray Computed | en_HK |
dc.subject.mesh | Transforming Growth Factor beta - genetics - pharmacology - therapeutic use | en_HK |
dc.title | Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1076-3279&volume=12&spage=3181&epage=3188&date=2006&atitle=Effect+of+recombinant+human+bone+morphogenetic+protein-2+on+mandibular+distraction+at+different+rates+in+a+rabbit+model | en_HK |
dc.identifier.email | Li, WZ:lwzheng@hku.hk | en_HK |
dc.identifier.authority | Li, WZ=rp01411 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1089/ten.2006.12.3181 | en_HK |
dc.identifier.pmid | 17518632 | - |
dc.identifier.scopus | eid_2-s2.0-33751576552 | en_HK |
dc.identifier.hkuros | 127036 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33751576552&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 12 | en_HK |
dc.identifier.issue | 11 | en_HK |
dc.identifier.spage | 3181 | en_HK |
dc.identifier.epage | 3188 | en_HK |
dc.identifier.isi | WOS:000242400200016 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Li, WZ=11241247300 | en_HK |
dc.identifier.scopusauthorid | Lim, KC=15119192900 | en_HK |