Generation of focused libraries by combinatorial biocatalysis with anti-Candidal activity: synthesis and in vitro study
Grant Data
Project Title
Generation of focused libraries by combinatorial biocatalysis with anti-Candidal activity: synthesis and in vitro study
Principal Investigator
Dr Tsang, Wai Kei
(Principal Investigator (PI))
Co-Investigator(s)
Professor Chan Edwin Ho Yin
(Co-Investigator)
Duration
16
Start Date
2009-01-01
Amount
79900
Conference Title
Generation of focused libraries by combinatorial biocatalysis with anti-Candidal activity: synthesis and in vitro study
Presentation Title
Keywords
broth dilution, Candida, combinatorial biocatalysis, in vitro
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
08070142
Grant Type
Research Fund for the Control of Infectious Diseases - Mini Grants
Funding Year
2008
Status
Completed
Objectives
To identify novel compounds with anti-Candidal activity, a compound library (n= 400) was screened. One compound, #205, was identified (MIC: 20microM) to inhibit growth of C. albicans; to further improve the pharmacological profile of this lead compound; to generate an array of focused libraries by acylation based on compound#205 using immobilized lipase; Modified acyl-derivatives of compound #205 will be evaluated by in vitro assay to delineate structure-activity relationship.