Novel Structure and Function of Human Sirtuins

Professor Hao, Quan   (Project Coordinator (PC))

Professor Huang Jiandong   (Co-principal investigator)

Professor Li Xiang David   (Co-principal investigator)

36

2015-03-01

5400000

Novel Structure and Function of Human Sirtuins

crystal structure, enzymatic function, epigenetics, inhibitor design, sirtuin

Structural Biology,Biochemistry

C7037-14G

Collaborative Research Fund (CRF) - Group Research Project

2014

Completed

1) To solve the crystal structures of SIRT4 and SIRT7 and investigate their potential enzymatic functions in vitro and in vivo. 2) To probe SIRT1-3’s defatty acyl modification activity and structural basis. 3) To develop mechanism-based inhibitors for all human sirtuins (SIRT1-7).