An exploration of psychotic symptoms and their vulnerability traits by evaluating large-scale semantic networks in psychotic disorders

Professor Chen, Eric Yu Hai   (Principal Investigator (PI))

Dr De Deyne Simon   (Co-Investigator)

Dr Chan Kit Wa   (Co-Investigator)

Dr Lee Ho Ming Edwin   (Co-Investigator)

Professor Elvevag Brita   (Co-Investigator)

Dr Hui Christy Lai Ming   (Co-Investigator)

Dr Chang Wing Chung   (Co-Investigator)

36

2016-01-01

634316

An exploration of psychotic symptoms and their vulnerability traits by evaluating large-scale semantic networks in psychotic disorders

computational modelling, schizophrenia, semantic networks, spreading activation

Psychosocial and Behavioural Research

Biology and Medicine (M)

17113315

General Research Fund (GRF)

2015

Completed

1 • To develop a novel methodology of studying large-scale semantic network model in patients and healthy participants. 2 • To study the hypothesis that these networks contain important information about psychopathology of psychosis that may be predictive of the course of symptoms. 3 • To compare 40 schizophrenia patients with active symptoms and after their resolution, with 40 age and gender matched healthy participants, in a six month longitudinal study. 4 • To explore the relationship between network measures and symptoms by comparing (1) between patients and healthy participants, and (2) within patient comparison from active psychotic state to stabilized remission state, using baseline network measures to predict 6-month clinical outcome.