Mechanism of OtuB1-mediated regulation in influenza virus infection

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Grant Data
Project Title
Mechanism of OtuB1-mediated regulation in influenza virus infection
Principal Investigator
Dr Sanyal, Sumana   (Principal Investigator (PI))
Co-Investigator(s)
Professor Ploegh Hidde   (Co-Investigator)
Duration
24
Start Date
2018-01-01
Amount
819393
Conference Title
Mechanism of OtuB1-mediated regulation in influenza virus infection
Presentation Title
Keywords
deubiquitylase, immune signaling, influenza virus, proteomics, ubiquitylation
Discipline
Cell Biology,Biochemistry
Panel
Biology and Medicine (M)
HKU Project Code
17112617
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 1. To characterize expression, localization and turnover of OtuB1 as a function of time in infection models with different strains of influenza virus 2 2. To understand the functional relevance of OtuB1 in the context of virus infection through genetic validation in knockout cells. 3 3. To define a biochemical pathway for OtuB1 by identifying its interactors and substrates using proximity-dependent labeling.
All Publications
TitleAuthor(s)Issue Date
 
OTUB1 is a key regulator of RIG-I-dependent immune signaling and is targeted for proteasomal degradation by influenza A NS1
Journal:Cell Reports
Akhee, SJBiquand, EMunoz-Moreno, RLe Quang, AMok, CKPWong, HHTEO, QWDoak, SAChin, AWHPoon, LMLTe Velthuis, AGarcia-Sastre, ADemeret, CSanyal, S
2020
 
Manipulation of autophagy by (+) RNA viruses
Journal:Seminars in Cell & Developmental Biology
Wong, HHSanyal, S
2020