Mechanism of OtuB1-mediated regulation in influenza virus infection

Dr Sanyal, Sumana   (Principal Investigator (PI))

Professor Ploegh Hidde   (Co-Investigator)

24

2018-01-01

819393

Mechanism of OtuB1-mediated regulation in influenza virus infection

deubiquitylase, immune signaling, influenza virus, proteomics, ubiquitylation

Cell Biology,Biochemistry

Biology and Medicine (M)

17112617

General Research Fund (GRF)

2017

Completed

1 1. To characterize expression, localization and turnover of OtuB1 as a function of time in infection models with different strains of influenza virus 2 2. To understand the functional relevance of OtuB1 in the context of virus infection through genetic validation in knockout cells. 3 3. To define a biochemical pathway for OtuB1 by identifying its interactors and substrates using proximity-dependent labeling.