Mechanism of OtuB1-mediated regulation in influenza virus infection


Grant Data
Project Title
Mechanism of OtuB1-mediated regulation in influenza virus infection
Principal Investigator
Dr Sanyal, Sumana   (Principal investigator)
Co-Investigator(s)
Professor Ploegh Hidde   (Co-Investigator)
Duration
24
Start Date
2018-01-01
Completion Date
2019-12-31
Amount
819393
Conference Title
Presentation Title
Keywords
deubiquitylase, influenza virus, immune signaling, proteomics, ubiquitylation
Discipline
Cell Biology,Biochemistry
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17112617
Grant Type
General Research Fund (GRF)
Funding Year
2017/2018
Status
Completed
Objectives
1 1. To characterize expression, localization and turnover of OtuB1 as a function of time in infection models with different strains of influenza virus 2 2. To understand the functional relevance of OtuB1 in the context of virus infection through genetic validation in knockout cells. 3 3. To define a biochemical pathway for OtuB1 by identifying its interactors and substrates using proximity-dependent labeling.