Epigenetic regulation of C/EBP-epsilon enhancer activity in MLL-rearranged leukemia


Grant Data
Project Title
Epigenetic regulation of C/EBP-epsilon enhancer activity in MLL-rearranged leukemia
Principal Investigator
Dr Ng, Ray Kit   (Principal investigator)
Co-Investigator(s)
Professor Leung Anskar Yu Hung   (Co-Investigator)
Duration
24
Start Date
2017-10-01
Completion Date
2019-09-30
Amount
972925
Conference Title
Presentation Title
Keywords
C/EBP-epsilon, DNA methylation, MLL-rearranged leukemia, enhancer, differentiation
Discipline
Blood/Hematology,Gene Regulation
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17114117
Grant Type
General Research Fund (GRF)
Funding Year
2017/2018
Status
Completed
Objectives
1 To identify the enhancer regions of C/EBPe in MLL-rearranged leukemia. 2 To investigate the chromosomal interactions mediated by C/EBPe enhancers and the associated key transcription factors. 3 To delineate the functional correlation between aberrant DNA methylation and C/EBPe enhancer activity in leukemia cell differentiation.