Validation of preclinical molecular diagnosed hypertrophic cardiomyopathy (HCM) using patient specific human induced pluripotent stem cell (hiPSC) platform-new perspectives in personalized drug-screening
Grant Data
Project Title
Validation of preclinical molecular diagnosed hypertrophic cardiomyopathy (HCM) using patient specific human induced pluripotent stem cell (hiPSC) platform-new perspectives in personalized drug-screening
Principal Investigator
Dr Lee, Yee Ki
(Principal Investigator (PI))
Duration
34
Start Date
2018-04-01
Amount
1197944
Conference Title
Validation of preclinical molecular diagnosed hypertrophic cardiomyopathy (HCM) using patient specific human induced pluripotent stem cell (hiPSC) platform-new perspectives in personalized drug-screening
Presentation Title
Keywords
Human induced, Hypertrophic, Sarcomeric gene
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
05161866
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2017
Status
Completed
Objectives
We hypothesize that patient-specific iPSC derived cardiomyocytes from patients with inherited HCM as detected by state-ofart genetic testing can be used for in-vitro drug screening. Specially, we aim to develop personalized targeted therapies for HCM patients based on the unique disease pathogenesis caused by individual mutations.