Molecular regulations and mechanistic functions of hypoxia-induced macropinocytosis in hepatocellular carcinoma.

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Grant Data
Project Title
Molecular regulations and mechanistic functions of hypoxia-induced macropinocytosis in hepatocellular carcinoma.
Principal Investigator
Dr Wong, Carmen Chak Lui   (Principal Investigator (PI))
Co-Investigator(s)
Professor Ng Irene Oi Lin   (Co-Investigator)
Duration
36
Start Date
2019-01-01
Completion Date
2021-12-31
Amount
972000
Conference Title
Molecular regulations and mechanistic functions of hypoxia-induced macropinocytosis in hepatocellular carcinoma.
Presentation Title
Keywords
EHD2, HCC, HIF, Hypoxia, metabolism
Discipline
Cancer,Cell Biology
Panel
Biology and Medicine (M)
HKU Project Code
17115218
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 To investigate the clinical implications of EHD2 in HCC 2 To delineate the regulation of EHD2 in HCC 3 To unravel the mechanistic roles of HIF/EHD2-mediated macropinocytosis in HCC 4 To evaluate the therapeutic potentials of targeting macropinocytosis in HCC