Role of Δ42PD-1 in Human Dendritic Cells during HIV-1 Infection

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Grant Data
Project Title
Role of Δ42PD-1 in Human Dendritic Cells during HIV-1 Infection
Principal Investigator
Professor Chen, Zhiwei   (Principal Investigator (PI))
Co-Investigator(s)
Dr Wang Hui   (Co-Investigator)
Dr Wong Yik Chun   (Co-Investigator)
Duration
36
Start Date
2019-01-01
Completion Date
2021-12-31
Amount
971983
Conference Title
Role of Δ42PD-1 in Human Dendritic Cells during HIV-1 Infection
Presentation Title
Keywords
AIDS, dendritic cell, HIV, Toll-like receptor 4, Δ42PD-1
Discipline
Others - Biological Sciences,Infection/Parasitology
Panel
Biology and Medicine (M)
HKU Project Code
17115818
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 The overall objective of the proposed study is to investigate the role of the recently discovered immune regulatory protein Δ42PD-1 in affecting human DC function during HIV-1 infection 2 Specific aim one: To determine the role of Δ42PD-1 in human DCs on regulating HIV-1 infection and transmission (year 1-1.5) 3 Specific aim two: To determine the role of Δ42PD-1 in regulating DC maturation and HIV-1 antigen presentation (year 1.5-3).