Development of ultrasound-responsive polymeric nanoreactors for retinoblastoma therapy
Grant Data
Project Title
Development of ultrasound-responsive polymeric nanoreactors for retinoblastoma therapy
Principal Investigator
Dr Wang, Weiping
(Principal Investigator (PI))
Co-Investigator(s)
Dr Lo Amy Cheuk Yin
(Co-Investigator)
Duration
36
Start Date
2019-08-01
Completion Date
2023-09-27
Amount
1499628
Conference Title
Development of ultrasound-responsive polymeric nanoreactors for retinoblastoma therapy
Keywords
Development, nanoreactors, polymeric, retinoblastoma, therapy, ultrasound-responsive
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
06173456
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
Completed
Objectives
We aim to develop a prodrug-based nanoreactor system that can produce hydrogen peroxide and chemotherapy drugs upon ultrasound application for efficient retinoblastoma therapy. Hypothesis to be tested: Ultrasound application can increase membrane permeability of polymersomes (nanoreactors) for glucose diffusion, which triggers the production of hydrogen peroxide and the release of camptothecin for synergistic oxidative therapy and chemotherapy.