GREM2: A novel regulator and marker of bone metabolism?
Grant Data
Project Title
GREM2: A novel regulator and marker of bone metabolism?
Principal Investigator
Dr Cheung, Ching Lung
(Principal Investigator (PI))
Duration
18
Start Date
2019-05-01
Amount
1414186
Conference Title
GREM2: A novel regulator and marker of bone metabolism?
Presentation Title
Keywords
bone, GREM2, marker, metabolism, novel, regulator
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
06173146
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
Completed
Objectives
Our published study and preliminary data showed that GREM2 is a susceptibility locus of osteoporosis. Its expression is induced by multiple key osteogenic molecules. Its circulating levels are potentially associated with BMD variation and reduced bone resorption. Therefore, the objectives of this proposal are to evaluate (1) the relationship of circulating GREM2 with bone metabolism in human; and (2) the role of GREM2 on osteoclastogenesis.