To explore the functional significance of retinoid signaling in EBV infection-mediated de-differentiation of nasopharyngeal epithelial cells

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Grant Data
Project Title
To explore the functional significance of retinoid signaling in EBV infection-mediated de-differentiation of nasopharyngeal epithelial cells
Principal Investigator
Dr Jia, Lin Jessica   (Principal Investigator (PI))
Co-Investigator(s)
Professor Tsao George Sai Wah   (Co-Investigator)
Duration
16
Start Date
2019-05-01
Amount
100000
Conference Title
To explore the functional significance of retinoid signaling in EBV infection-mediated de-differentiation of nasopharyngeal epithelial cells
Presentation Title
Keywords
de-differentiation, EBV, epithelial, infection-mediated, nasopharyngeal, retinoid
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
18170682
Grant Type
Health and Medical Research Fund - Mini Grant
Funding Year
2018
Status
Completed
Objectives
Undifferentiated nasopharyngeal carcinoma (NPC) is an endemic type of cancer in Hong Kong and Southern China. Epstein- Barr virus infection is believed to be an etiological factor for its pathogenesis. Previous studies have shown that ectopic overexpression of EBV oncoproteins would lead to the inhibition of epithelial cell differentiation; however, so far no direct evidence shows the regulatory roles of EBV infection per se on the differentiation properties of nasopharyngeal epithelial (NPE) cells.