The Pharmacological Effect and Mechanisms Study on Dendrobium Officinale - Yuye Decoction (DOY) to Improve Diabetic Nephropathy
Grant Data
Project Title
The Pharmacological Effect and Mechanisms Study on Dendrobium Officinale - Yuye Decoction (DOY) to Improve Diabetic Nephropathy
Principal Investigator
Dr Zhang, Yanbo
(Project Coordinator (PC))
Co-Investigator(s)
Dr Sze Cho Wing
(Co-Investigator)
Professor Tang Sydney Chi Wai
(Co-Investigator)
Professor Lao Lixing
(Co-Investigator)
Dr Tsui Kam Chuen
(Co-Investigator)
Duration
6
Start Date
2019-03-01
Completion Date
2019-08-31
Amount
119700
Conference Title
The Pharmacological Effect and Mechanisms Study on Dendrobium Officinale - Yuye Decoction (DOY) to Improve Diabetic Nephropathy
Keywords
Dendrobium Officinale, Diabetic, Nephropathy, Pharmacological Effect, Yuye Decoction (DOY)
Discipline
Chinese Medicine (clinical)
HKU Project Code
InP/025/19
Grant Type
Innovation and Technology Fund Internship Programme
Funding Year
2017
Status
Completed
Objectives
1) This study aim: To observe the therapeutic effects and mechanisms of the DOY formulation (Dendrobium officinale-Yuye Decoction) on rats with DN (diabetic nephropathy). 2) Methods and expected results: DN rat model will be treated with DOY for 12 weeks. After 12 weeks, the biochemical indexes in rat model such as urinary microalbumin, glycated hemoglobin, total cholesterol (TC), triglyceride (TG), Retinol-Binding Protein (RBP) and Homocysteine will be measured and expected to be decreased. ERK signal pathway will be inhibited and DN symptom should be improved. 3) Deliverables: DOY pharmacological effects in improved DN will be confirmed. A significant therapeutic efficacy of DOY for DN will be revealed. 4) Benefits: The company invested in this project will transform the project results into Chinese medicines product or health food product on the market. Statistics showed that there are 0.684 billion diabetic nephropathy patients worldwide. The project deliverables will bring considerable benefits.