The Anti-Tumor Effects of M1 Macrophage-Loaded Poly(ethylene) Glycol and Gelatin-Based Hydrogels on Hepatocellular Carcinoma
Grant Data
Project Title
The Anti-Tumor Effects of M1 Macrophage-Loaded Poly(ethylene) Glycol and Gelatin-Based Hydrogels on Hepatocellular Carcinoma
Principal Investigator
Dr Yeung, Wai Ho Oscar
(Principal Investigator (PI))
Co-Investigator(s)
Professor Man Kwan
(Co-Investigator)
Dr Zhang Xiang
(Co-Investigator)
Professor Kao Weiyuan John
(Co-Investigator)
Duration
12
Start Date
2018-04-01
Completion Date
2019-11-07
Amount
100000
Conference Title
The Anti-Tumor Effects of M1 Macrophage-Loaded Poly(ethylene) Glycol and Gelatin-Based Hydrogels on Hepatocellular Carcinoma
Keywords
biometerial, cancer immunotherapy, hydrogel, macrophages
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
05161816
Grant Type
Health and Medical Research Fund - Mini Grant
Funding Year
2017
Status
Completed
Objectives
Recently we reported that direct injection of M1 macrophages significantly induced tumor regression in vivo. Despite the promising result, a major limitation in translating this approach is the induction of acute inflammatory response. To improve the strategy, a biocompatible scaffold for cell delivery and support is essential for further development of novel immunotherapy against the disease. Here, we aimed to experiment the anti-tumor effects of a poly(ethylene glycol) diacrylate (PEGdA) and thiolated gelatin poly(ethylene glycol) (Gel-PEG-Cys) cross-linked hydrogels capsulated with M1 macrophages.