Combination approach to combat metallo-β-lactamase positive superbugs
Grant Data
Project Title
Combination approach to combat metallo-β-lactamase positive superbugs
Principal Investigator
Professor Sun, Hongzhe
(Project Coordinator (PC))
Co-Investigator(s)
Dr Kao Richard Yi Tsun
(Co-Investigator)
Dr Ho Pak Leung
(Co-Investigator)
Ms Hou Xuemei
(Co-Investigator)
Duration
60
Start Date
2019-04-01
Amount
13686087
Conference Title
Combination approach to combat metallo-β-lactamase positive superbugs
Keywords
bioinorganic chemistry, bismuth, combination therapy, metallo-β-lactamase, metals in medicine
Discipline
Chemical SciencesOthers - Medicine, Dentistry and Health
Panel
Physical Sciences (P)
HKU Project Code
R7070-18
Grant Type
Research Impact Fund (RIF)
Funding Year
2018
Status
On-going
Objectives
(1) To build up a platform for in vitro screening of metalloagents to restore antibiotics activity (2) To investigate the pharmacokinetics of lead bismuth compounds in different tissues and organs (3) To examine the efficacy of different bismuth compounds in the combination therapy for different types of models, e.g. urinary tract infection (UTI) and gastrointestinal infection (GI) (4) To provide an alternative strategy to tackle microbial infection and resistance prior to clinical trials (5) To educate junior scientists in translational research, and to stimulate markets for companies to invest in this field.