Targeting exosome Nidogen-1 as a potential treatment of liver cancer
Grant Data
Project Title
Targeting exosome Nidogen-1 as a potential treatment of liver cancer
Principal Investigator
Dr Mao, Xiaowen
(Principal Investigator (PI))
Co-Investigator(s)
Professor Yam Judy Wai Ping
(Co-Investigator)
Duration
36
Start Date
2020-04-01
Amount
1497744
Conference Title
Targeting exosome Nidogen-1 as a potential treatment of liver cancer
Keywords
Angiogenesis, Exosome, Hepatocellular carcinoma, Liver fibrosis, microenvironment, Nidogen-1
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
07182096
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2019
Status
On-going
Objectives
Exosomes are endosome-derived microvesicles released by cells into the extracellular environment. Exosomes of metastatic cells play pivotal role in hepatocellular carcinoma (HCC) development. Through proteomic profiling, NID1 was found to be highly expressed in exosomes of metastatic HCC cells.