Clinical outcome and future liver remnant regenerative response in laparoscopic versus open ALPPS: a randomized clinical trial.
Grant Data
Project Title
Clinical outcome and future liver remnant regenerative response in laparoscopic versus open ALPPS: a randomized clinical trial.
Principal Investigator
Professor Chan, Albert Chi Yan
(Principal Investigator (PI))
Co-Investigator(s)
Professor Man Kwan
(Co-Investigator)
Dr Ng Kevin Tak Pan
(Co-Investigator)
Duration
36
Start Date
2021-01-01
Completion Date
2023-12-31
Amount
829401
Conference Title
Clinical outcome and future liver remnant regenerative response in laparoscopic versus open ALPPS: a randomized clinical trial.
Keywords
ALPPS, hepatectomy, laparoscopy, liver hypertrophy, liver regeneration
Discipline
Surgical ResearchClinical Trials
Panel
Biology and Medicine (M)
HKU Project Code
17122320
Grant Type
General Research Fund (GRF)
Funding Year
2020
Status
Completed
Objectives
1 Primary objective To evaluate the amount of future liver remnant volume increment by percentage after stage I ALPPS 2 Secondary objective To evaluate the preoperative blood loss between laparoscopic and open stage 1 ALPPS 3 To evaluate the length of hospital stay after laparoscopic stage 1 ALPPS in comparison with open approach 4 To assess the overall morbidity and mortality rates after laparoscopic stage 1 ALPPS in comparison with open approach 5 To evaluate the inflammatory markers e.g. IL-6, IL-8 and TNF-alpha associated with inflammation and regeneration after stage 1 ALPPS between laparoscopic and open approach. This could be performed by - measurement of plasma inflammatory markers such as IL-6, IL-10, tumor necrosis factor at 6, 12 and 24 hours after stage I ALPPS, - polymerase chain reaction for IL-6, IL-10 and tumor necrosis factor in future liver remnant tissues obtained in stage I ALPPS and II ALPPS - immunohistochemical study to measure the expression of Ki-67 ( a marker for liver regeneration) in liver tissues obtained in stage I and II ALPPS